Description

Napsamycin C CAS NO 144379-26-0 is a specialized ansamycin-class antibiotic compound. It is valued for its potent biological activity, particularly as a selective inhibitor of bacterial RNA polymerase, making it a critical tool in microbiological research and drug discovery. This high-purity compound is essential for pharmaceutical R&D laboratories, biotechnology companies, and academic institutions focused on developing novel antibacterial agents and studying microbial genetics.

Application

• Antibacterial Research & Development: Serves as a key reference standard and active pharmaceutical ingredient (API) in the discovery and development of new antibiotic therapies.
• Mechanistic Studies: Used as a selective biochemical tool to investigate the function and inhibition of bacterial RNA polymerase in molecular biology and microbiology.
• Pharmacological Screening: Employed in high-throughput screening (HTS) assays to identify compounds with synergistic or antagonistic effects against bacterial targets.
• Academic Research: A vital reagent for university and institutional research projects exploring bacterial resistance mechanisms and novel modes of antibiotic action.
• Biotech Process Development: Used in the optimization of fermentation and synthesis processes for ansamycin-class compounds.
• Quality Control & Analytical Standards: Functions as a certified reference material (CRM) for the identification and quantification of Napsamycin C in complex matrices using HPLC, LC-MS, or other analytical techniques.

Basic Information

Product Name	Napsamycin C
CAS No.	144379-26-0
Molecular Formula	C39H48N2O9
Molecular Weight	688.81 g/mol
Synonyms	Napsamycin C; Benanomicin C; 144379-26-0; Ansamycin antibiotic C; Antibiotic C 144379-26-0; Benanomicin C (Napsamycin C); (2S,4aR,5R,6S,7S,8R,9S,11aR,13S,14aR,15R,16S,17R)-5,6,8,15,16-Pentahydroxy-7,9,13-trimethyl-2-[(1E)-1-propen-1-yl]-1,4,4a,5,6,7,8,9,11a,13,14,14a,15,16,17,18-hexadecahydro-2H-3,17-methanocyclopenta[a]phenanthro[10,1-bc]pyran-11(4H)-one
EINECS	Contact for details

Quality Control

Our Napsamycin C is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity suitable for research applications. Each lot undergoes comprehensive analytical testing, including HPLC for purity determination, NMR and MS for structural confirmation, and tests for residual solvents and moisture. A detailed Certificate of Analysis (COA) documenting identity, purity, and all relevant specifications is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry, cool place. Due to its hygroscopic (moisture-sensitive) nature, the container should be allowed to reach room temperature before opening to prevent condensation. For long-term storage, consider under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 5.0%
Heavy Metals	≤ 20 ppm
Residual Solvents (GC)	Meets ICH guidelines
Biological Activity	Assay available upon request

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.