Description

2'-Tfa-Nh-Dg CAS NO 144089-98-5 is a specialized nucleoside derivative, a key building block in oligonucleotide synthesis and pharmaceutical research. Its primary value lies in enabling the precise construction of modified DNA/RNA sequences, which is critical for developing advanced therapeutics and diagnostic tools. This high-purity intermediate is essential for researchers and manufacturers in the fields of antisense oligonucleotide (ASO) development, siRNA synthesis, and diagnostic probe manufacturing, where sequence fidelity and functional group compatibility are paramount.

Application

• Oligonucleotide Synthesis: A critical phosphoramidite precursor for the solid-phase synthesis of modified DNA and RNA strands.
• Antisense Therapy R&D: Used in the research and production of antisense oligonucleotides (ASOs) targeting specific genetic sequences.
• siRNA and miRNA Manufacturing: Enables the incorporation of specific modifications to enhance stability and efficacy of RNA interference (RNAi) agents.
• Diagnostic Probe Development: Serves as a building block for labeled probes used in PCR, FISH, and other molecular diagnostic assays.
• Pharmaceutical Intermediates: Acts as a key synthetic intermediate in the production of nucleoside-based antiviral and anticancer drug candidates.
• Bioconjugation and Labeling: The reactive amino group allows for site-specific conjugation with fluorophores, quenchers, or other functional molecules.

Basic Information

Product Name	2'-Tfa-Nh-Dg
CAS No.	144089-98-5
Molecular Formula	C17H19N7O6
Molecular Weight	417.38 g/mol
Synonyms	2'-Deoxy-2'-fluoro-2-N-(trifluoroacetyl)guanosine; 2'-Deoxy-2'-fluoro-N2-trifluoroacetylguanosine; 2'-F-N2-TFA-dG; 2'-Fluoro-2'-deoxy-N2-(trifluoroacetyl)guanosine; 9-[(2R,3R,4S,5R)-3-Fluoro-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]-2-(trifluoroacetylamino)-1H-purin-6-one; 2'-F-dG(N2-TFA); 2'-Fluoro-2'-deoxyguanosine, N2-trifluoroacetyl derivative
EINECS	Contact for details

Quality Control

Our 2'-Tfa-Nh-Dg is manufactured under strict quality control protocols to ensure the high purity and consistency required for sensitive pharmaceutical and diagnostic applications. Each batch is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to cGMP principles where applicable, and our quality systems are designed to support regulatory filings for drug substance intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This compound is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability. For long-term storage, consider storing under an inert atmosphere such as argon or nitrogen.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.