Description

Dmt-2'-F-Dgibu is a specialized fluorinated nucleoside phosphoramidite building block, a critical intermediate in the synthesis of oligonucleotides. Its value lies in enabling the precise incorporation of modified bases, which is essential for enhancing the stability, specificity, and therapeutic efficacy of synthetic DNA and RNA strands. This high-purity reagent is primarily needed by research institutions and pharmaceutical companies engaged in antisense therapy, siRNA development, diagnostic probe synthesis, and advanced genomic research.

Application

• Solid-Phase Oligonucleotide Synthesis: As a key phosphoramidite monomer for the automated synthesis of fluorinated oligonucleotides.
• Antisense Oligonucleotide (ASO) Development: For creating stable, nuclease-resistant therapeutic agents targeting specific mRNA sequences.
• Small Interfering RNA (siRNA) Production: To introduce fluorine modifications that improve pharmacokinetic properties and potency of RNAi therapeutics.
• Diagnostic Probe and Primer Design: Manufacturing labeled probes and primers with enhanced hybridization characteristics for PCR and FISH applications.
• Structural Biology Studies: Used to synthesize modified oligonucleotides for investigating nucleic acid structure, function, and protein interactions.
• Aptamer Development: For the selection and synthesis of chemically modified aptamers with increased affinity and stability for therapeutic and diagnostic use.

Basic Information

Product Name	Dmt-2'-F-Dgibu
CAS No.	144089-96-3
Molecular Formula	C41H49FN3O8P
Molecular Weight	761.82 g/mol
Synonyms	5'-O-(4,4'-Dimethoxytrityl)-2'-fluoro-2'-deoxyguanosine-3'-[(2-cyanoethyl)-(N,N-diisopropyl)]-phosphoramidite; 2'-Fluoro-2'-deoxyguanosine phosphoramidite (DMT protected); 2'-F-dG(Ibu) Phosphoramidite; 2'-Fluoro-2'-deoxyguanosine, 5'-O-[bis(4-methoxyphenyl)phenylmethyl]-3'-[(2-cyanoethoxy)(diisopropylamino)phosphino]-; Guanosine, 2'-deoxy-2'-fluoro-5'-O-[bis(4-methoxyphenyl)phenylmethyl]-3'-[2-cyanoethoxy(diisopropylamino)phosphinyl]-; 2'-F-dG Phosphoramidite; 2'-Fluoro-2'-deoxyguanosine β-cyanoethyl N,N-diisopropylphosphoramidite
EINECS	Contact for details

Quality Control

Our Dmt-2'-F-Dgibu is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity, suitable for sensitive oligonucleotide synthesis. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and moisture content. We adhere to industry-best practices and can provide material tailored to specific project requirements, including GMP-grade standards for therapeutic applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a freezer at -20°C ± 5°C under an inert atmosphere (argon or nitrogen) due to its moisture-sensitive and light-sensitive nature. Allow the sealed vial to equilibrate to room temperature before opening to prevent condensation and hydrolysis.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to reference spectrum
Purity (HPLC)	≥ 98.0%
Moisture Content (KF)	≤ 0.5%
Solubility	Soluble in anhydrous acetonitrile

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.