Description

Pneumocandin D(0) CAS NO 144087-99-0 is a potent semi-synthetic echinocandin-type antifungal agent and a key intermediate in the synthesis of advanced antifungal pharmaceuticals. Its primary value lies in its role as a critical precursor for manufacturing modern, broad-spectrum antifungal drugs, which are essential in treating severe systemic fungal infections. This high-purity intermediate is primarily needed by pharmaceutical R&D laboratories, active pharmaceutical ingredient (API) manufacturers, and contract development and manufacturing organizations (CDMOs) focused on antifungal therapeutics.

Application

• Pharmaceutical Intermediate: Serves as the principal building block for the synthesis of advanced echinocandin-class antifungal APIs, such as caspofungin and micafungin.
• Antifungal Drug Development: Used in research and development for creating new antifungal compounds targeting fungal cell wall synthesis.
• Biochemical Research: Employed as a reference standard in studies investigating the mechanism of action of glucan synthase inhibitors.
• Process Chemistry & Scale-Up: Critical for process optimization and scaling production routes for final drug substances in GMP environments.
• Quality Control & Analytical Standards: Utilized as a high-purity analytical standard for HPLC, LC-MS, and NMR methods to ensure batch consistency and purity of final drug products.

Basic Information

Product Name	Pneumocandin D(0)
CAS No.	144087-99-0
Molecular Formula	C50H81N7O16
Molecular Weight	1036.2 g/mol
Synonyms	Pneumocandin D0; (3S,6S,9S,11R,15S,18S,20R,21R,24S,25S,26S)-3-[(1R)-2-[(1S,2S,3S,4S)-1,2-Dihydroxy-3,4-dimethyl-1-(methylamino)hexyl]-4-hydroxy-6-methyloctanoyl]-6-[(1E)-1-butenyl]-11,20,21,25-tetrahydroxy-26-methyl-9,15,18-tris(2-methyl-1-oxopropoxy)-1,4,7,10,13,16,19,22-octaoxo-12-oxa-2,5,8,11,14,17,20,23-octaazacyclotetracosan-24-carboxamide; L-688,786; Echinocandin D0; FR901379 D0.
EINECS	Contact for details

Quality Control

Our Pneumocandin D(0) is manufactured under strict quality systems to ensure it meets the exacting standards required for pharmaceutical synthesis. Each batch is subjected to comprehensive analytical testing, including HPLC purity assay, identification by IR and NMR, and stringent control of related substances and residual solvents. A detailed Certificate of Analysis (COA) is provided with every shipment, and we support compliance with cGMP and ICH Q7 guidelines for pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or under refrigeration (2-8°C) as specified. Due to its hygroscopic nature, the container must be kept in a dry environment. For long-term storage, consider storing under an inert atmosphere to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 1.0%
Water Content (KF)	≤ 5.0%
Residual Solvents (GC)	Complies with ICH Q3C

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.