Description

Fmoc-D-Ala-Cl CAS NO 144073-15-4 is a protected amino acid derivative, specifically the Fmoc-chloride of D-alanine, used as a key chiral building block in solid-phase peptide synthesis (SPPS). This compound is critical for introducing the unnatural D-alanine residue into peptide chains, enabling the creation of peptides with enhanced stability and specific biological activity. It is an essential reagent for pharmaceutical R&D, biotechnology, and academic research focused on developing novel peptide-based therapeutics, diagnostics, and biochemical tools.

Application

• Solid-Phase Peptide Synthesis (SPPS): As an activated Fmoc-amino acid chloride for the efficient, racemization-minimized incorporation of D-alanine into custom peptide sequences.
• Pharmaceutical Research & Development: For the synthesis of peptide drug candidates, including antimicrobial peptides (AMPs) and hormone analogs where D-amino acids confer metabolic stability.
• Bioconjugation & Probe Development: Used to create peptide tags, linkers, or fluorescent probes with D-configuration for biochemical and cellular studies.
• Combinatorial Chemistry Libraries: Serves as a building block in generating diverse peptide libraries for high-throughput screening against biological targets.
• Academic & Institutional Research: A fundamental reagent in laboratories studying peptide structure-activity relationships, enzyme specificity, and chiral molecular recognition.
• Contract Manufacturing (CMO/CDMO): Supplied to organizations engaged in the GMP or non-GMP scale-up production of therapeutic peptides.

Basic Information

Product Name	Fmoc-D-Ala-Cl
CAS No.	144073-15-4
Molecular Formula	C18H16ClNO3
Molecular Weight	329.78 g/mol
Synonyms	Fmoc-D-alanine chloride; (R)-2-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)propanoyl chloride; N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-D-alanyl chloride; Fmoc-D-Ala-OCl; N-Fmoc-D-alanine acid chloride; Fmoc-D-Alanine Chloride; D-Alanine, N-[(9H-fluoren-9-ylmethoxy)carbonyl]-, chloride
EINECS	Contact for details

Quality Control

Our Fmoc-D-Ala-Cl is manufactured under strict quality controls to ensure high chemical purity and chiral integrity, critical for sensitive peptide synthesis applications. Each batch is supported by a comprehensive Certificate of Analysis (COA) detailing purity (typically >98% by HPLC), chiral purity, and identity confirmation. We adhere to relevant quality management standards to ensure reliable batch-to-batch consistency and supply chain traceability for our global B2B clients.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C (refrigerated) or as specified on the label. This material is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and reactivity. Allow the container to reach room temperature before opening to minimize moisture condensation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% ee (D-isomer)
Water Content (KF)	≤ 0.5%
Solubility	Soluble in dichloromethane, DMF, THF

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.