Description

(-)-Tioconazole is the single enantiomer of the broad-spectrum antifungal agent Tioconazole, characterized by its specific stereochemistry. This high-purity chiral intermediate is critical for pharmaceutical research and development, particularly in the synthesis of enantiomerically pure active pharmaceutical ingredients (APIs). It is essential for manufacturers and research institutions focused on antifungal drug development, chiral synthesis, and advanced pharmacological studies where stereochemical purity directly impacts biological activity and regulatory approval.

Application

• Pharmaceutical Intermediate: Key chiral building block for the synthesis of enantiopure antifungal APIs.
• Antifungal Research: Used as a reference standard and active component in R&D for novel topical and systemic antifungal agents.
• Chiral Synthesis: Employed in asymmetric synthesis and resolution processes to study structure-activity relationships (SAR).
• Biochemical Studies: Utilized in mechanistic studies to understand the inhibition of fungal lanosterol 14α-demethylase.
• Veterinary Medicine: Potential application in the development of antifungal treatments for animal health.
• Cosmeceutical Formulations: Investigated for use in dermal products targeting fungal infections, such as anti-dandruff shampoos.

Basic Information

Item	Detail
Product Name	(-)-Tioconazole
CAS No.	144025-09-2
Molecular Formula	C16H13Cl3N2OS
Molecular Weight	387.71 g/mol
Synonyms	(-)-Tioconazole; (R)-Tioconazole; (2R)-1-[2-[(2-Chloro-3-thienyl)methoxy]-2-(2,4-dichlorophenyl)ethyl]-1H-imidazole; Tioconazole Enantiomer; (R)-(-)-Tioconazole; Trosyd Impurity; Antifungal Agent R 42470 enantiomer
EINECS	Contact for details

Quality Control

Our (-)-Tioconazole is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity assessment by HPLC, to ensure it meets exacting standards for pharmaceutical research. A Certificate of Analysis (COA) detailing identity, purity, enantiomeric excess, and related substances is provided with every shipment to guarantee traceability and compliance.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under anhydrous conditions. For long-term storage, consider using a desiccant in the container.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	≥ 98.0%
Enantiomeric Purity (Chiral HPLC)	≥ 99.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.