Description

(+)-Tioconazole CAS NO 144025-08-1 is the single enantiomer of the broad-spectrum antifungal agent Tioconazole. This specific stereoisomer is of significant interest in pharmaceutical research and development due to its potential for enhanced biological activity and reduced side-effect profiles compared to the racemic mixture. It is primarily utilized by research institutions and pharmaceutical companies engaged in the development of novel antifungal therapeutics, chiral drug synthesis, and advanced pharmacological studies.

Application

• Pharmaceutical Intermediate: Serves as a key chiral building block in the synthesis of advanced antifungal drug candidates.
• Biochemical Research: Used as a reference standard and active compound in studies investigating the mechanism of action of azole antifungals.
• Chiral Catalyst Development: Employed in research focused on asymmetric synthesis and enantioselective catalysis.
• Analytical Standard: Provides a high-purity standard for method development and quality control in analytical laboratories (HPLC, GC).
• Structure-Activity Relationship (SAR) Studies: Essential for research aimed at understanding the impact of chirality on antifungal efficacy and toxicity.

Basic Information

Product Name	(+)-Tioconazole
CAS No.	144025-08-1
Molecular Formula	C16H13Cl3N2OS
Molecular Weight	387.71 g/mol
Synonyms	(+)-Tioconazole; (2R,3S)-Tioconazole; (R-(R*,S*))-1-(2-((2-Chloro-3-thienyl)methoxy)-2-(2,4-dichlorophenyl)ethyl)-1H-imidazole; Tioconazole Enantiomer; Trosyd Enantiomer; UK-20349 Enantiomer; Antifungal Agent UK-20349 (enantiomer); Gyno-Trosyd Enantiomer
EINECS	Contact for details

Quality Control

Our (+)-Tioconazole is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity determination by HPLC, to ensure identity, potency, and purity meet stringent research-grade specifications. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting all test results.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). The product is light-sensitive and should be handled accordingly to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	≥ 98.0%
Chiral Purity (Enantiomeric Excess)	≥ 99.0% ee
Related Substances (HPLC)	Total impurities ≤ 2.0%
Loss on Drying	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.