Description

5-(3-Amino-1-Propen-1-Yl)-2'-Deoxyuridine is a modified nucleoside analog, a key building block in advanced pharmaceutical and biochemical research. This compound is valued for its role as a versatile intermediate in the synthesis of novel antiviral and anticancer agents, particularly in the development of targeted nucleotide-based therapeutics. It is primarily utilized by research institutions, pharmaceutical R&D departments, and fine chemical manufacturers focused on nucleoside chemistry and prodrug development.

Application

• Pharmaceutical Intermediate: A critical precursor in the synthesis of experimental antiviral and antineoplastic (anticancer) nucleotide analogs.
• Biochemical Research: Used as a substrate or inhibitor in enzymatic studies to investigate DNA/RNA metabolism and repair mechanisms.
• Prodrug Development: Serves as a key scaffold for creating prodrugs designed for improved cellular uptake and targeted drug delivery.
• Antisense Oligonucleotide Synthesis: Employed in the research and development of modified antisense oligonucleotides for gene silencing applications.
• Diagnostic Probe Development: Utilized in the creation of labeled nucleoside probes for molecular diagnostics and imaging.
• Academic & Industrial R&D: Fundamental material for exploring new chemical entities (NCEs) in medicinal chemistry programs within academic and corporate laboratories.

Basic Information

Product Name	5-(3-Amino-1-Propen-1-Yl)-2'-Deoxyuridine
CAS No.	143908-73-0
Molecular Formula	C₁₂H₁₇N₃O₅
Molecular Weight	283.28 g/mol
Synonyms	5-(3-Aminoprop-1-en-1-yl)-2'-deoxyuridine; 5-(3-Aminoallyl)-2'-deoxyuridine; 2'-Deoxy-5-(3-aminoprop-1-en-1-yl)uridine; 5-(3-Aminopropenyl)-2'-deoxyuridine; dU-APA; APA-dU; 5-APA-2'-dUrd
EINECS	Contact for details

Quality Control

Our 5-(3-Amino-1-Propen-1-Yl)-2'-Deoxyuridine is manufactured under strict quality control protocols suitable for research and development applications. We ensure high purity and batch-to-batch consistency through advanced analytical techniques. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with each batch to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccant or inert atmosphere conditions.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC/IR)	Conforms to reference standard
Assay (HPLC)	≥ 95.0%
Purity (HPLC, Area%)	≥ 98.0%
Water Content (KF)	≤ 2.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.