Description

Ciprokiren CAS NO 143631-62-3 is a potent and selective renin inhibitor, representing a significant class of compounds for cardiovascular research. Its primary value lies in its ability to specifically target the renin-angiotensin-aldosterone system (RAAS), a key pathway in blood pressure regulation. This makes it a critical reference standard and active pharmaceutical ingredient (API) for researchers and developers in the pharmaceutical industry, particularly those focused on hypertension, heart failure, and related metabolic disorders.

Application

• Pharmaceutical Reference Standard: Used as a high-purity benchmark in analytical testing, method development, and quality control for drug manufacturing.
• Active Pharmaceutical Ingredient (API) Intermediate: Serves as a key building block in the synthesis of novel renin-inhibiting drug candidates.
• Biochemical Research: Employed in in vitro and in vivo studies to investigate the physiology and pharmacology of the renin-angiotensin system.
• Mechanism of Action Studies: Utilized to elucidate the binding kinetics and inhibitory pathways of renin inhibitors at the molecular level.
• Preclinical Development: Essential for pharmacokinetic, pharmacodynamic, and toxicology profiling in animal models during early drug discovery.

Basic Information

Product Name	Ciprokiren
CAS No.	143631-62-3
Molecular Formula	C30H41N5O4
Molecular Weight	535.68 g/mol
Synonyms	Ciprokiren; Ro 44-9375; (2S,4S,5S)-5-[(t-Butoxycarbonyl)amino]-4-hydroxy-6-phenyl-2-(1-phenylethyl)hexanoyl-L-histidyl-L-((1S,2R)-1-hydroxy-2,3-dihydro-1H-inden-2-yl)alaninamide; Ro 44-9375; Ro 449375; Ro-44-9375
EINECS	Contact for details

Quality Control

Our Ciprokiren is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing, including HPLC for purity, identity confirmation by IR and MS, and residual solvent analysis, to ensure it meets the stringent requirements for pharmaceutical research. A detailed Certificate of Analysis (COA) is provided with each shipment, confirming compliance with agreed specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept in a desiccated environment to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥98.0%
Water Content (KF)	≤1.0%
Residual Solvents (GC)	Complies with ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.