Description

3'-Azido-2'-Deoxy-5'-o-Dmt-Thymidine is a protected nucleoside analog, a critical building block in the synthesis of oligonucleotides and modified nucleic acids. Its value lies in its role as a key intermediate for introducing azido functionality, enabling advanced applications in click chemistry and bioconjugation. This high-purity compound is essential for researchers and manufacturers in pharmaceutical development, diagnostic probe synthesis, and advanced life science research, particularly for creating targeted therapeutics and molecular tools.

Application

• Oligonucleotide Synthesis: A vital phosphoramidite precursor for the solid-phase synthesis of azide-modified DNA and RNA strands.
• Click Chemistry Reagent: The azido group enables efficient, bioorthogonal copper-catalyzed azide-alkyne cycloaddition (CuAAC) for labeling and conjugating biomolecules.
• Antiviral Prodrug Development: Serves as a key intermediate in the research and synthesis of nucleoside reverse transcriptase inhibitors (NRTIs) and other antiviral agents.
• Bioconjugation & Probe Design: Used to create fluorescent, affinity, or therapeutic probes for targeted delivery and cellular imaging studies.
• Chemical Biology Research: Enables the study of nucleic acid structure, function, and interactions through site-specific modification.
• Pharmaceutical Intermediates: A high-value building block in the multi-step synthesis of complex active pharmaceutical ingredients (APIs).

Basic Information

Product Name	3'-Azido-2'-Deoxy-5'-o-Dmt-Thymidine
CAS No.	143526-93-6
Molecular Formula	C31H31N5O7
Molecular Weight	585.61 g/mol
Synonyms	3'-Azido-3'-deoxy-5'-O-(4,4'-dimethoxytrityl)thymidine; 3'-Azido-2',3'-dideoxy-5'-O-DMT-thymidine; 5'-O-(4,4'-Dimethoxytrityl)-3'-azido-2',3'-dideoxythymidine; 3'-Azido-5'-O-DMT-thymidine; AZT-DMT Precursor; DMT-Azido-dT; N3-Azido-dT(DMT); Azidothymidine DMT Ether
EINECS	Contact for details

Quality Control

Our 3'-Azido-2'-Deoxy-5'-o-Dmt-Thymidine is manufactured under strict quality systems to ensure high purity and batch-to-batch consistency suitable for research and pharmaceutical applications. Each lot is characterized by HPLC, NMR, and mass spectrometry to confirm identity and purity. Certificates of Analysis (COA) detailing all specifications are provided with every shipment. We support compliance with cGMP and ICH Q7 guidelines for advanced intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C or as indicated on the label. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability. For long-term storage, consider desiccation and an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH limits

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.