Description

7’-o-(4,4’-Dimethoxytrityloxy) Morpholino Thymine is a specialized phosphoramidite monomer, a critical building block in the automated synthesis of Morpholino antisense oligonucleotides. This compound matters for its role in creating highly stable and sequence-specific genetic research tools and therapeutic candidates. It is primarily needed by biotechnology and pharmaceutical R&D teams focused on gene function analysis, drug discovery, and the development of advanced antisense therapies.

Application

• Synthesis of Morpholino Oligomers: Primary use as a thymine monomer in solid-phase oligonucleotide synthesis for research and therapeutic applications.
• Antisense Technology Development: Key reagent for creating custom Morpholino oligos used to block specific mRNA sequences and modulate gene expression.
• Functional Genomics Research: Enables the production of probes for studying gene function, validation, and knockdown experiments in model organisms.
• Therapeutic Candidate Screening: Used in the early-stage development of potential antisense drugs targeting genetic diseases.
• Diagnostic Probe Assembly: Facilitates the construction of highly specific, nuclease-resistant probes for diagnostic assays.

Basic Information

Product Name	7’-o-(4,4’-Dimethoxytrityloxy) Morpholino Thymine
CAS No.	143485-05-6
Molecular Formula	C36H39N3O7
Molecular Weight	625.72 g/mol
Synonyms	DMTr-Morpholino-Thymine; 5'-O-(4,4'-Dimethoxytrityl)thymidine 3'-(2-(morpholino)-N,N-diisopropylphosphoramidite); Thymine Morpholino Monomer DMT-protected; PMO Monomer (Thymine); Morpholino phosphoramidite (Thymine); Gene Tools monomer precursor; Antisense oligonucleotide synthesis reagent; N-(2-(4-Morpholinyl)ethyl)-N-(4-((4-(dimethylamino)phenyl)(4-methoxyphenyl)methyl)phenoxy)acetyl)thymine
EINECS	Contact for details

Quality Control

Every batch of our 7’-o-(4,4’-Dimethoxytrityloxy) Morpholino Thymine is manufactured and tested under strict quality management systems to ensure consistency and reliability for sensitive oligonucleotide synthesis. We provide comprehensive Certificates of Analysis (COA) detailing purity, identity, and moisture content, supporting compliance with cGMP guidelines for research-grade materials. Our quality commitment ensures the reagent meets the high standards required for reproducible genetic research and development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C under an inert atmosphere (argon or nitrogen) due to its hygroscopic and light-sensitive nature. Allow the sealed container to reach room temperature before opening to prevent moisture condensation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC/MS)	Conforms to structure
Assay (HPLC)	≥ 95.0%
Purity (HPLC, 254 nm)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Solubility	Soluble in anhydrous acetonitrile, DCM

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.