Description

3Tctp (Lamivudine-5'-Triphosphate) (Aqueous Solution) is a high-purity, biologically active nucleotide analog triphosphate, a critical building block for nucleic acid research and development. This compound serves as a chain terminator, making it an essential tool for studying viral replication mechanisms, particularly for HIV and hepatitis B. It is primarily utilized by pharmaceutical R&D teams, diagnostic assay developers, and academic researchers in molecular biology for applications in virology, enzymology, and antiviral drug discovery. Consistent quality and reliable supply are paramount for ensuring reproducible experimental and developmental outcomes.

Application

• Antiviral Mechanism Studies: Used as a substrate analog to investigate the inhibition of viral reverse transcriptase enzymes.
• Biochemical Assay Development: Essential for creating and validating enzymatic assays to screen for new antiviral compounds.
• Nucleic Acid Synthesis Research: Employed in controlled DNA/RNA synthesis experiments to study polymerase fidelity and termination.
• Pharmaceutical R&D: A key reference standard and intermediate in the development and testing of nucleoside-based therapeutics.
• Diagnostic Kit Manufacturing: Incorporated into diagnostic assays for detecting viral load and drug resistance mutations.
• Academic Research: Fundamental reagent for university and institutional research in virology, biochemistry, and structural biology.

Basic Information

Item	Detail
Product Name	3Tctp (Lamivudine-5'-Triphosphate) (Aqueous Solution)
CAS No.	143188-53-8
Molecular Formula	C9H17N3O12P3
Molecular Weight	491.15 g/mol
Synonyms	Lamivudine Triphosphate; 3TC-TP; (-)-2',3'-Dideoxy-3'-thiacytidine 5'-triphosphate; 2',3'-Dideoxy-3'-thiacytidine-5'-triphosphate; BCH-189 triphosphate; GR-109714X triphosphate; 3TCTP; 3TC 5'-Triphosphate
EINECS	Contact for details

Quality Control

Our 3Tctp (Lamivudine-5'-Triphosphate) (Aqueous Solution) is manufactured under strict quality management systems to ensure the highest standards of purity and batch-to-batch consistency, suitable for sensitive research and development applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and stability parameters. We adhere to relevant industry guidelines to support our clients' compliance needs in pharmaceutical and diagnostic development.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store frozen at -20°C or below. The aqueous solution is easily oxidized; it is recommended to store under an inert atmosphere such as argon or nitrogen and to aliquot to minimize freeze-thaw cycles. Keep container tightly sealed in a dry, well-ventilated area.

Specification

Item	Specification
Appearance	Clear, colorless to slightly yellow aqueous solution
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to reference standard
Assay (HPLC)	≥ 95%
pH	6.0 - 8.0
Endotoxin	< 0.1 EU/µmol
Solvent	Water

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.