Description

2,2-Difluoro-1,3-benzodioxole-4-carbonyl chloride is a highly reactive and versatile fluorinated aromatic acid chloride building block. Its core value lies in its ability to introduce the 2,2-difluoro-1,3-benzodioxole moiety into complex molecules, a key structural feature in advanced material science and pharmaceutical development. This compound is essential for researchers and manufacturers in the agrochemical and pharmaceutical industries, particularly for synthesizing novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: A critical precursor for the synthesis of active pharmaceutical ingredients (APIs), especially those requiring the difluorobenzodioxole scaffold for enhanced metabolic stability and bioavailability.
• Agrochemical Synthesis: Used in the development of next-generation herbicides, fungicides, and insecticides, where the fluorine atoms and benzodioxole structure contribute to efficacy and environmental profile.
• Material Science: Serves as a monomer or cross-linking agent for creating specialty polymers, coatings, and liquid crystals with unique optical or electronic properties.
• Organic Synthesis Building Block: Employed in academic and industrial R&D for constructing complex heterocyclic compounds and fluorinated aromatic systems via amidation or esterification reactions.
• Ligand and Catalyst Development: Useful for preparing novel ligands and organocatalysts used in asymmetric synthesis and transition metal catalysis.

Basic Information

Product Name	2,2-Difluoro-1,3-benzodioxole-4-carbonyl chloride
CAS No.	143096-86-0
Molecular Formula	C8H3ClF2O3
Molecular Weight	220.56 g/mol
Synonyms	4-(Chlorocarbonyl)-2,2-difluoro-1,3-benzodioxole; 2,2-Difluorobenzodioxole-4-carbonyl chloride; 2,2-Difluoro-1,3-benzodioxole-4-carboxylic acid chloride; 1,3-Benzodioxole-4-carbonyl chloride, 2,2-difluoro-; 4-Carboxy-2,2-difluoro-1,3-benzodioxole chloride
EINECS	Contact for details

Quality Control

Our 2,2-Difluoro-1,3-benzodioxole-4-carbonyl chloride is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and IR spectroscopy, to ensure high purity and consistency. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are provided with every shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic and moisture-sensitive nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent hydrolysis. Keep away from strong acids, bases, and oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline solid or powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.