Description

N6-Benzoyl-8-Benzyloxy-2'-Deoxyadenosine is a chemically modified nucleoside derivative, serving as a crucial building block and protecting group reagent in advanced oligonucleotide synthesis. This compound is essential for researchers and manufacturers developing novel therapeutic agents, including antisense oligonucleotides and aptamers. It is primarily utilized by pharmaceutical R&D laboratories, biotechnology companies, and fine chemical suppliers focused on nucleic acid chemistry and drug discovery.

Application

• Oligonucleotide Synthesis: Acts as a key phosphoramidite precursor or protected monomer in solid-phase synthesis of DNA and RNA analogs.
• Antisense Drug Development: Used in the research and production of antisense oligonucleotides for therapeutic applications targeting genetic diseases.
• Protecting Group Chemistry: The N6-benzoyl and 8-benzyloxy groups provide orthogonal protection for the adenine base during complex multi-step synthetic sequences.
• Bioconjugation & Probe Synthesis: A starting material for creating labeled nucleosides used in diagnostic probes and imaging agents.
• Academic & Industrial Research: Employed in chemical biology studies to investigate nucleic acid structure, function, and interactions.
• Process Development: Serves as an intermediate in the scale-up and optimization of nucleotide-based active pharmaceutical ingredients (APIs).

Basic Information

Product Name	N6-Benzoyl-8-Benzyloxy-2'-Deoxyadenosine
CAS No.	142979-40-6
Molecular Formula	C24H21N5O4
Molecular Weight	443.46 g/mol
Synonyms	8-Benzyloxy-N6-benzoyl-2'-deoxyadenosine; 2'-Deoxy-N6-benzoyl-8-benzyloxyadenosine; 8-O-Benzyl-N6-benzoyl-2'-deoxyadenosine; N6-Benzoyl-8-O-benzyl-2'-deoxyadenosine; 2'-Deoxyadenosine, N6-benzoyl-8-benzyloxy-; Bz-8-Bzl-dA; dA(Bz,Bzl); Contact for additional synonyms.
EINECS	Contact for details

Quality Control

Our N6-Benzoyl-8-Benzyloxy-2'-Deoxyadenosine is produced under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and residual solvent analysis. A Certificate of Analysis (COA) detailing all specifications is provided with every shipment to ensure traceability and compliance with your research or cGMP guidelines, as required.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.