Description

(3A,5B,7A,12A)-3-Amino-7,12-Dihydroxycholan-24-Oic Acid Methyl Ester is a high-purity, functionalized bile acid derivative of significant interest in advanced pharmaceutical research and development. This compound serves as a critical synthetic intermediate for the preparation of novel therapeutic agents and diagnostic tools. It is primarily utilized by research institutions and pharmaceutical companies engaged in the development of liver-targeted drugs, metabolic disorder treatments, and specialized contrast agents.

Application

• Pharmaceutical Intermediate: A key building block for the synthesis of novel bile acid-based therapeutics targeting liver diseases, metabolic syndromes, and cholesterol regulation.
• Research Chemical: Used in academic and industrial R&D for studying bile acid transporters, receptor interactions, and metabolic pathways.
• Contrast Agent Precursor: Serves as a starting material for developing hepatobiliary-specific MRI or CT contrast media due to its inherent liver-targeting properties.
• Prodrug Synthesis: Utilized in creating prodrugs designed for enhanced oral bioavailability and targeted delivery to the liver and intestines.
• Bioconjugation: The amino and hydroxyl functional groups allow for conjugation with peptides, proteins, or other molecules for targeted drug delivery systems.
• Reference Standard: Employed as a high-purity analytical standard in quality control laboratories for method development and validation in pharmaceutical analysis.

Basic Information

Product Name	(3A,5B,7A,12A)-3-Amino-7,12-Dihydroxycholan-24-Oic Acid Methyl Ester
CAS No.	142975-31-3
Molecular Formula	C₂₅H₄₃NO₅
Molecular Weight	437.62 g/mol
Synonyms	3α-Amino-7α,12α-dihydroxy-5β-cholan-24-oic Acid Methyl Ester; Methyl 3α-Amino-7α,12α-dihydroxy-5β-cholan-24-oate; 3-Amino-7,12-dihydroxycholanic Acid Methyl Ester; Tauromethylcholate Precursor; Amino Dihydroxy Methyl Cholanate; Cholic Acid Amino Methyl Ester Derivative; 5β-Cholan-24-oic Acid, 3-amino-7,12-dihydroxy-, Methyl Ester, (3α,5β,7α,12α)-
EINECS	Contact for details

Quality Control

Our (3A,5B,7A,12A)-3-Amino-7,12-Dihydroxycholan-24-Oic Acid Methyl Ester is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, chiral analysis, and identity confirmation via NMR and mass spectrometry, to ensure it meets the stringent requirements for pharmaceutical research. Certificates of Analysis (COA) with full traceability are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and light-sensitive; therefore, containers must be kept tightly sealed in a desiccated environment away from direct light exposure to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Specific Rotation	Contact for details
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.