Description

N6-Benzoyl-8-Hydroxy-2'-Deoxyadenosine is a chemically modified nucleoside derivative, specifically engineered for advanced research and pharmaceutical development. This compound is valued for its role as a key synthetic intermediate and a critical building block in the creation of novel oligonucleotides and nucleotide-based therapeutics. It is essential for researchers and manufacturers in the fields of antiviral drug discovery, oligonucleotide synthesis, and biochemical research, where precise molecular modifications are required.

Application

• Oligonucleotide Synthesis: A crucial phosphoramidite precursor for the solid-phase synthesis of modified DNA strands.
• Antiviral/Anticancer Research: Serves as a core scaffold in the development of nucleoside analog prodrugs targeting viral polymerases and cellular enzymes.
• Biochemical Probes: Used to study enzyme mechanisms, including methyltransferases and glycosylases, due to its modified base structure.
• Pharmaceutical Intermediates: A high-purity building block for the cGMP manufacturing of active pharmaceutical ingredients (APIs) in nucleotide therapeutics.
• Diagnostic Assay Development: Incorporated into probes and primers for sensitive detection systems, including PCR and sequencing.

Basic Information

Product Name	N6-Benzoyl-8-Hydroxy-2'-Deoxyadenosine
CAS No.	142948-08-1
Molecular Formula	C17H17N5O5
Molecular Weight	371.35 g/mol
Synonyms	8-Hydroxy-2'-deoxy-N6-benzoyladenosine; N6-Benzoyl-8-oxo-2'-deoxyadenosine; 2'-Deoxy-8-hydroxy-N6-benzoyladenosine; Bz-8-OH-dA; N6-Bz-8-OH-dAdo; 8-Hydroxy-N6-benzoyl-2'-deoxyadenosine; 142948-08-1; N6-Benzoyl-8-hydroxy-deoxyadenosine
EINECS	Contact for details

Quality Control

Every batch of N6-Benzoyl-8-Hydroxy-2'-Deoxyadenosine is manufactured under a strict quality management system. Our products undergo rigorous analytical testing, including HPLC, NMR, and MS, to ensure high chemical purity and structural identity. Certificates of Analysis (COA) with detailed chromatographic data are provided to support your research and regulatory submissions.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C (refrigerated) or as indicated on the label or COA. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.