Description

8-Benzyloxy-2'-Deoxyadenosine is a chemically modified nucleoside derivative, specifically a 2'-deoxyadenosine analog protected at the 8-position with a benzyloxy group. This modification is critical for its role as a versatile building block and intermediate in synthetic organic chemistry and medicinal research. It is primarily utilized by researchers and manufacturers in the pharmaceutical, biotechnology, and life sciences sectors for applications such as oligonucleotide synthesis and the development of novel therapeutic agents.

Application

• Oligonucleotide Synthesis: Serves as a key protected intermediate in the solid-phase synthesis of modified DNA strands for research and diagnostic probes.
• Medicinal Chemistry: Used as a building block in the design and synthesis of nucleoside-based drug candidates, including potential antivirals and anticancer agents.
• Biochemical Research: Acts as a substrate or inhibitor in enzymatic studies to investigate nucleotide metabolism and related biological pathways.
• Prodrug Development: Employed in the creation of prodrug forms of nucleoside analogs to enhance bioavailability and targeting.
• Chemical Biology: Utilized for the site-specific incorporation of modifications into nucleic acids to study structure-function relationships.
• Reference Standard: Functions as a high-purity analytical standard for quality control and method development in analytical laboratories.

Basic Information

Product Name	8-Benzyloxy-2'-Deoxyadenosine
CAS No.	142948-07-0
Molecular Formula	C₁₇H₁₉N₅O₄
Molecular Weight	357.36 g/mol
Synonyms	8-O-Benzyl-2'-deoxyadenosine; 8-(Benzyloxy)-9-(2-deoxy-β-D-erythro-pentofuranosyl)-9H-purin-6-amine; 2'-Deoxy-8-benzyloxyadenosine; 8-Benzyloxydeoxyadenosine; 8-Bzl-dA; N6-Amino-8-benzyloxy-9-(2-deoxy-β-D-ribofuranosyl)purine
EINECS	Contact for details

Quality Control

Our 8-Benzyloxy-2'-Deoxyadenosine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and tests for residual solvents and moisture content. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specifications and test results to ensure compliance with your research and production requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C or as specified on the label or COA. Due to its hygroscopic nature, the container should be kept sealed under an inert atmosphere (e.g., nitrogen or argon) for long-term storage to prevent moisture absorption and degradation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.