Description

3'-Azido-3',5'-Dideoxythymidine-5'-Methylphosphonic Acid Diphosphate is a chemically modified nucleoside analog, specifically a phosphorylated derivative of AZT (Zidovudine). This compound is of significant interest in pharmaceutical research and development due to its role as a potential prodrug or active metabolite in antiviral therapies. It is primarily utilized by researchers and manufacturers in the life sciences sector for the synthesis of novel therapeutic agents, particularly those targeting viral replication mechanisms.

Application

• Antiviral Drug Research: Serves as a key biochemical precursor and active pharmaceutical ingredient (API) intermediate in the development of nucleoside reverse transcriptase inhibitors (NRTIs).
• Biochemical Probe Development: Used in molecular biology and enzymology studies to investigate the mechanisms of viral polymerases and cellular kinases.
• Prodrug Synthesis: Acts as a critical building block for creating advanced prodrug formulations aimed at improving bioavailability and targeted delivery of antiviral compounds.
• Medicinal Chemistry: Employed in structure-activity relationship (SAR) studies to design and synthesize new analogs with enhanced efficacy and reduced toxicity profiles.
• Pharmaceutical Reference Standard: Used as a high-purity analytical standard for quality control and regulatory compliance in API manufacturing.

Basic Information

Product Name	3'-Azido-3',5'-Dideoxythymidine-5'-Methylphosphonic Acid Diphosphate
CAS No.	142802-35-5
Molecular Formula	C11H16N5O12P3
Molecular Weight	527.19 g/mol
Synonyms	AZT Diphosphate Methylphosphonate; 3'-Azido-3'-deoxythymidine-5'-methylphosphonic acid diphosphate; AZT-MP-PP; Zidovudine Methylphosphonate Diphosphate; 5'-(Methylphosphonodiphosphoryl)-3'-azido-3',5'-dideoxythymidine; Thymidine, 3'-azido-3'-deoxy-5'-[methylphosphonodiphosphate]; AZT Triphosphate Analog
EINECS	Contact for details

Quality Control

Our 3'-Azido-3',5'-Dideoxythymidine-5'-Methylphosphonic Acid Diphosphate is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation via NMR and mass spectrometry, to ensure it meets the stringent requirements for pharmaceutical research. Certificates of Analysis (COA) with detailed chromatographic data are provided to guarantee traceability, consistency, and compliance with your research or development protocols.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a desiccated environment. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity. Allow the container to reach room temperature before opening to minimize moisture condensation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥95.0%
Water Content (KF)	≤1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.