Description

8-Chloroadenosine-3',5'-Cyclic Monophosphorothioate, Sp-Isomer Sodium Salt is a chemically modified, cell-permeable analog of cyclic adenosine monophosphate (cAMP) designed for advanced biochemical research. This compound matters as a potent and selective activator of protein kinase A (PKA), offering superior stability against phosphodiesterase hydrolysis compared to its unmodified counterpart. It is primarily needed by researchers in pharmacology, neuroscience, and cell signaling for studying cAMP-dependent pathways, making it a critical tool for drug discovery and understanding cellular regulation.

Application

• Biochemical Research: As a stable, cell-permeable activator for studying cAMP-dependent protein kinase (PKA) signaling cascades in vitro and in cell-based assays.
• Neuroscience Studies: Investigation of synaptic plasticity, neurotransmitter release, and long-term potentiation (LTP) mechanisms where PKA plays a key role.
• Cardiovascular Research: Exploration of cardiac muscle contraction, ion channel regulation, and the effects of β-adrenergic receptor stimulation.
• Metabolic Pathway Analysis: Probing the role of PKA in glycogen metabolism, lipolysis, and insulin secretion.
• Drug Discovery & Screening: Serving as a reference compound or positive control in high-throughput screens for modulators of the cAMP/PKA pathway.
• Cell Biology: Studies focused on cell differentiation, proliferation, and apoptosis regulated by cAMP levels.

Basic Information

Product Name	8-Chloroadenosine-3',5'-Cyclic Monophosphorothioate, Sp-Isomer Sodium Salt
CAS No.	142754-28-7
Molecular Formula	C10H10ClN5O5PSNa
Molecular Weight	449.70 g/mol
Synonyms	8-Chloro-cAMPS, Sp-isomer, sodium salt; 8-Cl-cAMPS; 8-Chloroadenosine 3',5'-cyclic monophosphorothioate, (Sp)-isomer; Rp-8-Cl-cAMPS (common mislabeling reference); cAMP analog, 8-chloro-; Protein Kinase A Activator, 8-Chloro-; Sodium 8-chloro-adenosine-3',5'-cyclic phosphorothioate (Sp-isomer)
EINECS	Contact for details

Quality Control

Our 8-Chloroadenosine-3',5'-Cyclic Monophosphorothioate, Sp-Isomer Sodium Salt is produced under stringent conditions to ensure high purity and batch-to-batch consistency, suitable for sensitive research applications. Each lot undergoes comprehensive analytical characterization, including HPLC, NMR, and mass spectrometry. A Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with every shipment to support your quality assurance protocols.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This product is hygroscopic (moisture-sensitive). For long-term storage, consider desiccation. Allow the vial to equilibrate to room temperature before opening to minimize moisture absorption.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 5.0%
Solubility	Soluble in water, DMSO

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.