Description

(+)-(R)-Pantoprazole CAS NO 142706-18-1 is the single enantiomer, R-isomer of the proton pump inhibitor pantoprazole. This high-purity chiral intermediate is critical for the development and manufacturing of enantiomerically pure active pharmaceutical ingredients (APIs) targeting gastric acid-related disorders. It is essential for pharmaceutical R&D laboratories and manufacturers seeking to produce advanced, patent-protected formulations with improved pharmacokinetic profiles and reduced side effects.

Application

• Pharmaceutical Intermediate: Primary building block for the synthesis of enantiomerically pure pantoprazole sodium sesquihydrate and other advanced proton pump inhibitor APIs.
• Chiral Drug Development: Used in research and development of new single-enantiomer therapeutics to enhance efficacy and safety profiles.
• Reference Standard: Serves as a high-purity chemical reference standard (CRS) for analytical method development, validation, and quality control in pharmaceutical laboratories.
• Process Chemistry: Key starting material (KSM) in GMP-compliant manufacturing processes for finished dosage forms.
• Metabolite Studies: Utilized in preclinical and clinical studies to investigate the metabolism and pharmacokinetics of the R-enantiomer.

Basic Information

Item	Details
Product Name	(+)-(R)-Pantoprazole
CAS No.	142706-18-1
Molecular Formula	C16H14F2N3O4S
Molecular Weight	382.36 g/mol
Synonyms	(R)-(+)-Pantoprazole; Dexlansoprazole Impurity; (R)-Pantoprazole; Pantoprazole R-Isomer; 5-(Difluoromethoxy)-2-[[(3,4-dimethoxy-2-pyridinyl)methyl]sulfinyl]-1H-benzimidazole (R)-form; 1H-Benzimidazole, 5-(difluoromethoxy)-2-[[(3,4-dimethoxy-2-pyridinyl)methyl]sulfinyl]-, (R)-; BY1023 R-Isomer
EINECS	Contact for details

Quality Control

Our (+)-(R)-Pantoprazole is manufactured under strict quality management systems. Each batch is subjected to comprehensive analytical testing, including chiral HPLC for enantiomeric excess (ee) determination, to ensure it meets the high-purity standards required for pharmaceutical applications. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided and can be tailored to meet specific pharmacopeial (e.g., USP, EP) or client specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.5%
Enantiomeric Excess (Chiral HPLC)	≥99.0%
Related Substances (HPLC)	Total impurities ≤1.5% Any single unknown impurity ≤0.5%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Loss on Drying	≤0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.