Description

S-Pantoprazole CAS NO 142678-35-1 is the single enantiomer of pantoprazole, a proton pump inhibitor (PPI) that acts as a potent and long-lasting inhibitor of gastric acid secretion. This high-purity active pharmaceutical ingredient (API) is critical for developing more targeted and efficient anti-ulcerative therapies with potentially improved pharmacokinetic profiles. It is primarily required by pharmaceutical manufacturers and research institutions engaged in the formulation of advanced gastrointestinal medications, novel drug delivery systems, and chiral drug development.

Application

• Pharmaceutical API: Core active ingredient in prescription medications for treating gastroesophageal reflux disease (GERD), peptic ulcers, and Zollinger-Ellison syndrome.
• Chiral Drug Synthesis: Serves as a key chiral building block for synthesizing enantiomerically pure pharmaceutical compounds, leveraging its specific stereochemistry.
• Formulation R&D: Used in research and development of new dosage forms such as enteric-coated tablets, delayed-release capsules, and intravenous formulations.
• Generic Drug Manufacturing: Essential for producing bioequivalent generic versions of patented S-pantoprazole-based drugs.
• Reference Standard: Employed as a high-purity analytical standard in quality control laboratories for HPLC, LC-MS, and pharmacopeial testing.
• Clinical Trial Materials: Supplied as a GMP-grade intermediate for the production of clinical trial batches for new drug applications (NDAs).

Basic Information

Product Name	S-Pantoprazole
CAS No.	142678-35-1
Molecular Formula	C16H14F2N3O4S
Molecular Weight	382.36 g/mol
Synonyms	(S)-Pantoprazole; Dexrabeprazole; Pantoprazole Sodium Sesquihydrate (S-isomer); (+)-Pantoprazole; (S)-5-(Difluoromethoxy)-2-[[(3,4-dimethoxy-2-pyridinyl)methyl]sulfinyl]-1H-benzimidazole; BY1023 (S-form); Pantoprazole Impurity L (USP); SK&F96022 (S-isomer)
EINECS	Contact for details

Quality Control

Our S-Pantoprazole is manufactured under strict quality management systems. It undergoes rigorous analytical testing to ensure compliance with high-purity standards, including identity, purity, and impurity profile verification against specifications such as USP monographs. A comprehensive Certificate of Analysis (COA) detailing results for assay, enantiomeric excess, related substances, residual solvents, and heavy metals is provided with each batch to guarantee traceability and consistency for pharmaceutical applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a low-humidity environment to prevent moisture absorption and degradation. For long-term storage, consider the use of desiccants.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time conforms to reference standard
Assay (HPLC)	98.0% - 102.0% (on anhydrous basis)
Enantiomeric Purity	≥ 99.0% (S-isomer)
Related Substances (HPLC)	Total impurities ≤ 1.0% Any individual impurity ≤ 0.5%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.