Description

2,2'-Anhydro-1-(3'-Deoxy-3'-Iodoarabinofuranosyl)Thymine is a specialized nucleoside analog, a key intermediate in the synthesis of modified oligonucleotides and antiviral agents. Its value lies in its precise chemical structure, which allows for targeted modifications to nucleic acid backbones, enabling advanced research in drug discovery and molecular biology. This high-purity compound is essential for pharmaceutical R&D laboratories, biotechnology companies, and academic institutions focused on developing novel therapeutics, antisense oligonucleotides, and diagnostic probes.

Application

• Pharmaceutical Intermediate: Critical building block for the synthesis of novel antiviral and anticancer nucleoside analogs.
• Oligonucleotide Synthesis: Used in the research and development of modified antisense oligonucleotides and siRNA constructs.
• Biochemical Research: Serves as a tool compound for studying enzyme mechanisms, particularly those involving DNA polymerases and nucleoside kinases.
• Prodrug Development: A precursor in the creation of prodrugs designed for improved cellular uptake and metabolic stability.
• Diagnostic Probe Synthesis: Employed in the manufacture of labeled nucleotides for diagnostic assays and imaging.
• Academic & Contract Research: Fundamental material for cutting-edge research in medicinal chemistry and molecular biology within universities and CROs.

Basic Information

Product Name	2,2'-Anhydro-1-(3'-Deoxy-3'-Iodoarabinofuranosyl)Thymine
CAS No.	142545-11-7
Molecular Formula	C10H11IN2O5
Molecular Weight	366.11 g/mol
Synonyms	3'-Deoxy-3'-iodothymidine 2',3'-anhydro derivative; 1-[(2R,3S,5R)-3-Iodo-5-(hydroxymethyl)oxolan-2-yl]-5-methyl-1,2,3,4-tetrahydropyrimidine-2,4-dione; 3'-Iodo-2',3'-dideoxythymidine 2',3'-anhydro derivative; 2,2'-Anhydro-3'-deoxy-3'-iodothymidine; 3'-Deoxy-3'-iodo-2',3'-anhydrothymidine; Anhydro-3'-iodothymidine; Iodinated Thymidine Anhydronucleoside
EINECS	Contact for details

Quality Control

Our 2,2'-Anhydro-1-(3'-Deoxy-3'-Iodoarabinofuranosyl)Thymine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via NMR and mass spectrometry, to ensure it meets the high-purity standards required for pharmaceutical research. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with every shipment to guarantee traceability and compliance.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under anhydrous conditions. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines
Heavy Metals	< 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.