Description

Adenosine-3',5'-Cyclic Monophosphorothioate, Rp-Isomer Sodium Salt CAS NO 142439-94-9 is a chemically modified, cell-permeable analog of cyclic adenosine monophosphate (cAMP) designed as a potent and selective inhibitor of cAMP-dependent protein kinase (PKA). This compound matters for researchers and developers because it provides a powerful tool for dissecting intracellular signaling pathways and studying the physiological roles of PKA in cellular processes. It is essential for high-value applications in pharmaceutical research, biochemical assay development, and cell biology studies, particularly for investigating cardiovascular, neurological, and metabolic disorders.

Application

• Biochemical Research: As a selective PKA inhibitor for studying cAMP-mediated signal transduction pathways in vitro.
• Pharmaceutical Development: Used in target validation and screening assays for drug discovery programs focused on PKA-related diseases.
• Cell Biology Studies: Investigating the role of PKA in cellular functions such as gene expression, metabolism, and ion channel regulation.
• Neuroscience Research: Probing cAMP/PKA signaling in neuronal plasticity, memory formation, and neurotransmitter release.
• Cardiovascular Research: Studying PKA's involvement in cardiac contractility, smooth muscle relaxation, and vascular tone.
• Diagnostic Reagent Manufacturing: A key component in the formulation of specialized kits for kinase activity and inhibition assays.

Basic Information

Product Name	Adenosine-3',5'-Cyclic Monophosphorothioate, Rp-Isomer Sodium Salt
CAS No.	142439-94-9
Molecular Formula	C10H11N5NaO5PS
Molecular Weight	391.26 g/mol
Synonyms	Rp-cAMPS sodium salt; Adenosine 3',5'-cyclic monophosphorothioate, Rp-isomer, sodium salt; Rp-Adenosine 3',5'-cyclic monophosphorothioate; Rp-cAMPS, Na salt; cAMP antagonist Rp-isomer; Protein Kinase A Inhibitor (Rp-isomer); 8-[(Rp)-Adenosine-3',5'-cyclic monophosphorothioate] sodium salt; RP 8-CPT-cAMPS sodium salt
EINECS	Contact for details

Quality Control

Our Adenosine-3',5'-Cyclic Monophosphorothioate, Rp-Isomer Sodium Salt is manufactured under strict quality systems to ensure batch-to-batch consistency and high purity for research applications. Each lot undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation via spectroscopic methods. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting the purity, assay, and results of all specified tests to meet the stringent requirements of the life sciences industry.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a desiccator before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 98.0%
Assay	≥ 95.0% (anhydrous basis)
Water Content (KF)	≤ 5.0%
Solubility	Soluble in water, DMSO

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.