Description

Benzo[B]Thiophene-2-Carbonyl Chloride, 6-Fluoro- (9Ci) is a high-value fluorinated heterocyclic building block, specifically an acid chloride derivative, that serves as a critical intermediate in advanced organic synthesis. Its core value proposition lies in enabling the precise introduction of the benzo[b]thiophene scaffold with a reactive carbonyl chloride group and a fluorine substituent, which is essential for modulating the biological activity and physicochemical properties of target molecules. This compound is primarily needed by research and development teams in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients, particularly in drug discovery programs targeting a range of therapeutic areas.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of potential drug candidates, especially in medicinal chemistry projects exploring kinase inhibitors, enzyme modulators, and other small-molecule therapeutics.
• Agrochemical Research: Used in the development of new herbicides, fungicides, and insecticides where the benzo[b]thiophene core contributes to biological efficacy.
• Material Science Precursor: Serves as a monomer or functionalization agent in the creation of specialized polymers and organic electronic materials.
• Chemical Biology Probes: Employed in the design and synthesis of molecular probes and tags for studying biological processes and target engagement.
• Custom Synthesis & Contract Manufacturing: A vital starting material for fine chemical manufacturers offering bespoke synthesis services to the life sciences sector.

Basic Information

Product Name	Benzo[B]Thiophene-2-Carbonyl Chloride, 6-Fluoro- (9Ci)
CAS No.	142329-20-2
Molecular Formula	C10H4ClFOS
Molecular Weight	226.65 g/mol
Synonyms	6-Fluorobenzo[b]thiophene-2-carbonyl chloride; 6-Fluoro-1-benzothiophene-2-carbonyl chloride; 2-Benzothiophenecarbonyl chloride, 6-fluoro-; 6-Fluoro-benzo[b]thiophene-2-carboxylic acid chloride; 6-Fluorobenzo[b]thiophene-2-carboxylic acid chloride; 6-Fluoro-2-benzothienecarbonyl chloride
EINECS	Contact for details

Quality Control

Our Benzo[B]Thiophene-2-Carbonyl Chloride, 6-Fluoro- (9Ci) is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity, suitable for demanding research and development applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to relevant industry standards and can provide material tailored to specific project requirements, including research-grade and development-scale quantities.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (typically 15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) to prevent decomposition. Keep away from strong acids, bases, and oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0% (Area %)
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.