Description

(+)-Ketoconazole CAS NO 142128-59-4 is the pharmacologically active enantiomer of the broad-spectrum antifungal agent ketoconazole. This high-purity chiral intermediate is critical for the development and manufacturing of enantiomerically pure antifungal pharmaceuticals and research compounds. It is primarily utilized by pharmaceutical R&D laboratories, fine chemical manufacturers, and academic institutions focused on chiral synthesis and antifungal activity studies.

Application

• Chiral Intermediate in Pharmaceutical Synthesis: Serves as a key building block for the production of enantiomerically pure antifungal drugs.
• Reference Standard for Analytical Development: Used in HPLC and other chromatographic methods for method development, validation, and quality control of ketoconazole-based products.
• Biochemical Research: Employed in studies investigating the stereospecific inhibition of fungal cytochrome P450 enzymes, such as CYP51A1 (lanosterol 14α-demethylase).
• Preclinical & Clinical Research: Utilized in the formulation of specific enantiomer preparations for pharmacological and toxicological evaluation.
• Asymmetric Catalysis Studies: Acts as a model substrate or ligand in research focused on chiral resolution techniques and asymmetric synthesis.

Basic Information

Product Name	(+)-Ketoconazole
CAS No.	142128-59-4
Molecular Formula	C26H28Cl2N4O4
Molecular Weight	531.43 g/mol
Synonyms	(+)-cis-1-Acetyl-4-[4-[[2-(2,4-dichlorophenyl)-2-(1H-imidazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy]phenyl]piperazine; (2R,4S)-Ketoconazole; Dextro-Ketoconazole; (R-cis)-Ketoconazole; Enantiomerically Pure Ketoconazole; (R*,R*)-(+)-Ketoconazole; NSC 759985
EINECS	Contact for details

Quality Control

Our (+)-Ketoconazole is manufactured under strict quality management systems. Each batch is subjected to comprehensive analytical testing, including chiral purity determination by HPLC, to ensure it meets stringent specifications for pharmaceutical research and development. A Certificate of Analysis (COA) detailing identity, purity, and chiral excess is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and must be kept in a dry environment to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	≥98.0%
Chiral Purity (Enantiomeric Excess)	≥99.0%
Loss on Drying	≤0.5%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm
Related Substances (HPLC)	Individual impurity ≤0.5%; Total impurities ≤1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.