Description

(2R,4R)-Ketoconazole CAS NO 142128-58-3 is a specific stereoisomer of the broad-spectrum antifungal agent ketoconazole, prized for its defined stereochemistry and high purity. This enantiomerically pure compound is critical for advanced pharmaceutical research and development, particularly in studying structure-activity relationships and developing novel therapeutic formulations. It is primarily sought by pharmaceutical manufacturers, research institutions, and fine chemical suppliers engaged in antifungal drug development, chiral synthesis, and analytical reference standard production.

Application

• Pharmaceutical Intermediate: A key chiral building block in the synthesis of advanced antifungal APIs (Active Pharmaceutical Ingredients).
• Research & Development: Used as a high-purity reference standard in analytical method development, pharmacokinetic studies, and metabolic research.
• Chiral Catalyst/Reagent: Employed in asymmetric synthesis due to its defined stereocenters for constructing complex molecular architectures.
• Biochemical Research: A tool compound for investigating sterol biosynthesis pathways and cytochrome P450 enzyme inhibition.
• Formulation Development: Used in pre-formulation studies for topical and systemic antifungal drug products.
• Quality Control: Serves as a certified reference material (CRM) for HPLC/LC-MS assay calibration in pharmaceutical QC laboratories.

Basic Information

Product Name	(2R,4R)-Ketoconazole
CAS No.	142128-58-3
Molecular Formula	C26H28Cl2N4O4
Molecular Weight	531.43 g/mol
Synonyms	(2R,4R)-Ketoconazole; (2R-cis)-Ketoconazole; cis-1-Acetyl-4-[4-[[2-(2,4-dichlorophenyl)-2-(1H-imidazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy]phenyl]piperazine; (2R,4R)-1-Acetyl-4-(4-((2-(2,4-dichlorophenyl)-2-(1H-imidazol-1-ylmethyl)-1,3-dioxolan-4-yl)methoxy)phenyl)piperazine; Ketoconazole (2R,4R)-isomer; Enantiomerically pure Ketoconazole; (R,R)-Ketoconazole
EINECS	Contact for details

Quality Control

Our (2R,4R)-Ketoconazole is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral HPLC for enantiomeric excess determination, to ensure high chemical and stereochemical purity suitable for pharmaceutical research. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	≥ 98.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Related Substances (HPLC)	Individual impurity ≤ 0.5%; Total impurities ≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.