Description

α-L-Erythro-Pentofuranosyl Chloride-2-Deoxy-Bis(4-Methyl Benzoate) is a high-purity, protected nucleoside derivative, a critical building block in advanced organic synthesis. Its primary value lies in enabling the precise construction of complex oligonucleotides and modified nucleic acids, where control over stereochemistry and functional group protection is paramount. This compound is essential for researchers and manufacturers in the pharmaceutical and biotechnology sectors, particularly those developing novel antisense oligonucleotides, siRNA therapeutics, and diagnostic probes.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel nucleoside-based antiviral and anticancer agents.
• Oligonucleotide Synthesis: Serves as a protected monomer for the solid-phase or solution-phase assembly of custom DNA/RNA sequences.
• Antisense & siRNA Therapeutics: Used in the research and production of therapeutic oligonucleotides designed to target specific mRNA sequences.
• Diagnostic Probe Development: Enables the creation of labeled nucleic acid probes for genetic testing and molecular diagnostics.
• Glycochemistry Research: Acts as a chiral synthon for the study and synthesis of complex carbohydrate and nucleoside analogs.
• Process Chemistry & Scale-Up: Supplied under stringent quality control for use in process development and cGMP manufacturing.

Basic Information

Product Name	α-L-Erythro-Pentofuranosyl Chloride-2-Deoxy-Bis(4-Methyl Benzoate)
CAS No.	141846-57-3
Molecular Formula	C21H21ClO6
Molecular Weight	404.84 g/mol
Synonyms	2-Deoxy-3,5-di-O-p-toluoyl-α-L-erythro-pentofuranosyl Chloride; 1-Chloro-2-deoxy-3,5-di-O-(4-methylbenzoyl)-α-L-erythro-pentofuranose; 3,5-Di-O-p-toluoyl-2-deoxy-α-L-erythro-pentofuranosyl Chloride; α-L-2'-Deoxyribofuranosyl Chloride 3',5'-Bis(4-methylbenzoate); Protected L-Nucleoside Chloride; LNA Monomer Precursor; L-2'-Deoxyribose Derivative
EINECS	Contact for details

Quality Control

Every batch of α-L-Erythro-Pentofuranosyl Chloride-2-Deoxy-Bis(4-Methyl Benzoate) is manufactured and tested under a strict quality management system. We provide comprehensive analytical data to ensure identity, purity, and consistency, supporting your regulatory and research requirements. A detailed Certificate of Analysis (COA) with specifications for HPLC purity, chiral purity, water content (KF), and residual solvents is supplied with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C (refrigerated) or as indicated on the label or COA. This material is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity. Keep container tightly sealed in a desiccated environment after opening.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference standard
Assay (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0%
Water Content (KF)	≤ 0.5%
Related Substances (HPLC)	Individual impurity ≤ 0.5%; Total impurities ≤ 1.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.