Description

3-Azi-1-((2-Acetamido-2-Deoxy-1-Glucopyranosyl)Thio)Butane is a sophisticated thioglycoside derivative that combines a reactive azide functional group with an N-acetylglucosamine (GlcNAc) moiety. This unique bifunctional structure makes it a valuable intermediate for advanced bioconjugation and chemical biology research, enabling the site-specific modification of biomolecules. It is primarily utilized by researchers and manufacturers in the pharmaceutical and biotechnology sectors for developing targeted therapeutics, diagnostic probes, and novel glycoconjugates.

Application

• Bioconjugation Reagent: Used for the chemoselective modification of proteins, antibodies, and other biomolecules via click chemistry (e.g., copper-catalyzed azide-alkyne cycloaddition).
• Glycobiology Research: Serves as a key building block for synthesizing complex oligosaccharides, glycopeptides, and glycomimetics to study carbohydrate-protein interactions.
• Drug Discovery: Employed in the synthesis of antibody-drug conjugates (ADCs) and other targeted drug delivery systems where precise glycosylation is critical.
• Diagnostic Probe Development: Facilitates the creation of fluorescent or affinity-labeled probes for imaging and detecting specific cellular targets.
• Material Science: Applied in surface functionalization to create bioactive coatings or biosensors with specific carbohydrate recognition properties.
• Enzyme Inhibitor Synthesis: Acts as a precursor for developing inhibitors of glycosidases or glycosyltransferases, which are relevant in metabolic disease and cancer research.

Basic Information

Product Name	3-Azi-1-((2-Acetamido-2-Deoxy-1-Glucopyranosyl)Thio)Butane
CAS No.	141411-41-8
Molecular Formula	C13H23N4O5S
Molecular Weight	347.41 g/mol
Synonyms	1-Thio-β-D-glucosamine pentaacetate azide derivative; 4-Azidobutyl 2-acetamido-2-deoxy-1-thio-β-D-glucopyranoside; N-Acetylglucosamine thioglycoside azide; GlcNAc-β-S-(CH2)4N3; Azido-functionalized thioglycoside; 2-Acetamido-2-deoxy-1-S-(4-azidobutyl)-1-thio-β-D-glucopyranose; 4-Azidobutyl 1-thio-2-acetamido-2-deoxy-β-D-glucopyranoside; Azidobutyl GlcNAc thioether
EINECS	Contact for details

Quality Control

Our products undergo rigorous quality testing to ensure compliance with industry standards for research and development. Each batch is characterized using advanced analytical techniques to confirm identity, purity, and stability. Certificates of Analysis (COA) detailing specifications such as purity (by HPLC), identity (by NMR and IR), and impurity profiles are available upon request. We adhere to a quality management system to ensure batch-to-batch consistency and traceability.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store desiccated at -20°C or below. This compound is moisture-sensitive (hygroscopic) and should be handled under an inert atmosphere when possible to prevent degradation. Allow the sealed container to equilibrate to room temperature before opening to minimize moisture condensation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.