Description

3-Pyridinecarbonyl Chloride, 4-(Difluoromethoxy)- (9Ci) is a specialized heterocyclic acid chloride derivative, serving as a critical building block in advanced organic synthesis. Its value lies in the unique reactivity of the acid chloride group and the presence of the difluoromethoxy substituent, which are essential for introducing specific pharmacophores into target molecules. This high-purity intermediate is primarily needed by R&D and production teams in the pharmaceutical and agrochemical industries for the development of novel active ingredients.

Application

• Pharmaceutical Intermediate: Key synthon for the synthesis of active pharmaceutical ingredients (APIs), particularly in medicinal chemistry programs targeting central nervous system (CNS) disorders and metabolic diseases.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides and insecticides, where the difluoromethoxy group can enhance biological activity and metabolic stability.
• Ligand and Catalyst Development: Serves as a precursor for creating novel pyridine-based ligands used in asymmetric catalysis and metal-organic frameworks (MOFs).
• Material Science Research: Employed in the synthesis of functionalized polymers and advanced organic materials with specific electronic or surface properties.
• Custom Synthesis and Contract Manufacturing: A vital reagent for fine chemical manufacturers offering bespoke synthesis services for clients in life sciences.

Basic Information

Item	Details
Product Name	3-Pyridinecarbonyl Chloride, 4-(Difluoromethoxy)- (9Ci)
CAS No.	141311-99-1
Molecular Formula	C7H4ClF2NO2
Molecular Weight	207.56 g/mol
Synonyms	4-(Difluoromethoxy)nicotinoyl chloride; 4-(Difluoromethoxy)pyridine-3-carbonyl chloride; 3-Carbonyl chloride-4-(difluoromethoxy)pyridine; Nicotinoyl chloride, 4-(difluoromethoxy)-; Isonicotinoyl chloride, 6-(difluoromethoxy)- (related isomer); 141311-99-1; 4-DFM-Nicotinoyl Chloride
EINECS	Contact for details

Quality Control

Every batch of 3-Pyridinecarbonyl Chloride, 4-(Difluoromethoxy)- (9Ci) is manufactured under strict quality management systems. We provide comprehensive analytical documentation to ensure traceability and consistency for your critical synthesis workflows. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are supplied with each shipment, supporting compliance with cGMP and ISO 9001 standards for research and production use.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic and highly volatile nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent moisture absorption and decomposition. Keep away from strong acids, bases, and oxidizing agents.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid or solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0% (Area %)
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.