Description

(R)-2-(2,4-Difluorfenyl)-3-(1H-1,2,4-Triazool-1-Yl)Propaan-1,2-Diol is a high-purity, chiral triazole derivative of significant interest in advanced pharmaceutical synthesis. This compound serves as a critical chiral building block or intermediate in the development of novel active pharmaceutical ingredients (APIs), particularly antifungal agents. It is essential for research institutions and pharmaceutical manufacturers engaged in the synthesis of enantiomerically pure therapeutic compounds. The precise stereochemistry and functional groups make it a valuable scaffold for medicinal chemistry and process development.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and commercial synthesis of potent triazole-based antifungal APIs.
• Medicinal Chemistry Research: Used as a building block for structure-activity relationship (SAR) studies and the discovery of new bioactive molecules.
• Process Chemistry & Scale-Up: Employed in the development and optimization of synthetic routes for pharmaceutical manufacturing.
• Reference Standard: Serves as a high-purity analytical standard for quality control and regulatory submissions in drug development.
• Asymmetric Synthesis: Utilized in reactions requiring a specific enantiomer to achieve desired pharmacological activity and reduce side effects.

Basic Information

Product Name	(R)-2-(2,4-Difluorfenyl)-3-(1H-1,2,4-Triazool-1-Yl)Propaan-1,2-Diol
CAS No.	141113-41-9
Molecular Formula	C11H10F2N3O2
Molecular Weight	254.21 g/mol
Synonyms	(2R)-2-(2,4-Difluorophenyl)-3-(1H-1,2,4-triazol-1-yl)propane-1,2-diol; (R)-2-(2,4-Difluorophenyl)-3-(1H-1,2,4-triazol-1-yl)-1,2-propanediol; (R)-Fluconazole Intermediate; (R)-2,4-Difluoro-α,2-bis(1H-1,2,4-triazol-1-ylmethyl)benzyl alcohol (related); (R)-enantiomer of a triazole diol; FCZ Impurity/Intermediate
EINECS	Contact for details

Quality Control

Our (R)-2-(2,4-Difluorfenyl)-3-(1H-1,2,4-Triazool-1-Yl)Propaan-1,2-Diol is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity verification by HPLC, to ensure compliance with exacting standards for pharmaceutical intermediates. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are available upon request to support your regulatory and quality assurance requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after opening to prevent degradation from atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Chiral Purity (Chiral HPLC)	≥99.0% ee
Related Substances (HPLC)	Total impurities ≤2.0%
Loss on Drying	≤0.5%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.