Description

2,4-Difluorophenyl Isothiocyanate is a versatile and reactive organofluorine building block essential for advanced chemical synthesis. Its isothiocyanate functional group enables efficient derivatization, making it a critical intermediate for creating complex molecules with tailored properties. This high-purity compound is primarily sought after by researchers and manufacturers in the pharmaceutical and agrochemical industries for developing new active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: Key building block for synthesizing novel drug candidates, particularly in medicinal chemistry programs targeting kinase inhibitors and other small-molecule therapeutics.
• Agrochemical Synthesis: Used in the research and production of advanced pesticides and herbicides, where the difluorophenyl moiety can enhance biological activity and metabolic stability.
• Ligand and Chelator Preparation: Serves as a precursor for creating specialized ligands used in catalysis, metal complexation, and diagnostic imaging agents.
• Material Science Research: Employed in the development of functional polymers, liquid crystals, and advanced organic electronic materials due to its reactive handle and fluorine content.
• Bioconjugation Chemistry: Useful for modifying peptides, proteins, and other biomolecules by reacting with amine groups to form thiourea linkages.
• Chemical Biology Probes: Acts as a starting material for creating activity-based probes and other tools for studying enzymatic activity and biological pathways.

Basic Information

Product Name	2,4-Difluorophenyl Isothiocyanate
CAS No.	141106-52-7
Molecular Formula	C7H3F2NS
Molecular Weight	171.17 g/mol
Synonyms	1,3-Difluoro-4-isothiocyanatobenzene; 2,4-Difluorophenyl Mustard Oil; 2,4-Difluorobenzene Isothiocyanate; Isothiocyanic Acid 2,4-Difluorophenyl Ester; 4-Isothiocyanato-1,3-difluorobenzene; 2,4-DFPITC
EINECS	Contact for details

Quality Control

Every batch of 2,4-Difluorophenyl Isothiocyanate is manufactured and tested under strict quality management protocols to ensure high purity and consistency. Our products undergo rigorous analytical testing, including HPLC, GC, and NMR, to confirm identity and meet stringent impurity profiles. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with each shipment, ensuring full traceability and compliance with your research or production requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid or low-melting solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.