Description

5''-o-(Dimethoxytrityl)-S6-(2,4-Dinitrophenyl)-N2-Phenylacetyl-2''-Deoxythioguanosine is a sophisticated, multi-protected nucleoside derivative designed for advanced oligonucleotide synthesis. This compound is critical for researchers and manufacturers requiring high-purity, chemically modified building blocks for the development of therapeutic nucleic acids and diagnostic probes. It is primarily utilized by the pharmaceutical, biotechnology, and life science research sectors engaged in antisense, siRNA, and aptamer development.

Application

• Solid-Phase Oligonucleotide Synthesis (SPOS): Serves as a key phosphoramidite precursor for the controlled incorporation of modified thioguanosine bases into synthetic oligonucleotides.
• Therapeutic Nucleic Acid Development: Essential for creating research-scale and GMP-grade oligonucleotides for antisense, siRNA, and gene therapy applications.
• Diagnostic Probe Manufacturing: Used in the synthesis of labeled probes for hybridization assays, where the DNP (2,4-dinitrophenyl) group can act as a hapten for detection.
• Medicinal Chemistry & Drug Discovery: A valuable intermediate for exploring structure-activity relationships (SAR) in nucleoside-based drug candidates.
• Bioconjugation and Labeling Studies: The orthogonal protecting groups (DMT, DNP, Phenacetyl) allow for selective deprotection and further functionalization.

Basic Information

Product Name	5''-o-(Dimethoxytrityl)-S6-(2,4-Dinitrophenyl)-N2-Phenylacetyl-2''-Deoxythioguanosine
CAS No.	141076-17-7
Molecular Formula	C45H39N7O9S
Molecular Weight	853.90 g/mol
Synonyms	5'-O-DMT-S6-DNP-N2-PhenAc-dG(s); DMT-DNP-Thio-dG(PhenAc); N2-Phenylacetyl-5'-O-(4,4'-dimethoxytrityl)-2'-deoxy-6-thioguanosine S-(2,4-dinitrophenyl) derivative; 2'-Deoxy-6-thioguanosine, N2-(phenylacetyl)-5'-O-[bis(4-methoxyphenyl)phenylmethyl]-, 6-(2,4-dinitrophenyl) thioether; Protected 6-Thio-2'-deoxyguanosine derivative; DMT-S6-DNP-N2-Pac-dG; Oligonucleotide Synthesis Intermediate (Thio-dG)
EINECS	Contact for details

Quality Control

Our production of this high-value nucleoside intermediate adheres to stringent quality protocols suitable for research and pharmaceutical development. Each batch is characterized by advanced analytical techniques including HPLC, NMR, and mass spectrometry to ensure structural identity and purity. Certificates of Analysis (COA) detailing purity, moisture content, and identity are provided with every shipment. We support development under ISO 9001 quality management systems, with scalability to cGMP standards for advanced therapeutic applications.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere (e.g., argon or nitrogen) in a desiccated environment. This compound is hygroscopic (moisture-sensitive) and light-sensitive. Allow the sealed container to equilibrate to room temperature before opening to prevent condensation and moisture ingress.

Specification

Item	Specification
Appearance	Yellow to orange solid
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 1.0%
Solubility	Soluble in acetonitrile, DMF, DMSO

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.