Description

3'-Methylamino-2',3'-Dideoxyribosylthymine is a modified nucleoside analog of significant interest in pharmaceutical research and development. This compound serves as a critical intermediate in the synthesis of novel antiviral and anticancer agents, particularly those targeting viral polymerases and cellular DNA replication. It is primarily utilized by research institutions and pharmaceutical companies engaged in the development of nucleoside-based therapeutics. The precise chemical structure of this analog allows for targeted modifications to enhance drug efficacy and selectivity.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of experimental antiviral and antineoplastic (anticancer) drugs.
• Biochemical Research: Used as a substrate or inhibitor in enzymatic studies related to DNA/RNA metabolism and polymerase function.
• Medicinal Chemistry: Serves as a core scaffold for structure-activity relationship (SAR) studies to optimize pharmacokinetic properties.
• Antiviral Agent Development: Investigated for potential activity against a range of viruses, including retroviruses and herpesviruses.
• Preclinical Studies: Employed in in vitro and in vivo testing to evaluate therapeutic potential and mechanism of action.

Basic Information

Product Name	3'-Methylamino-2',3'-Dideoxyribosylthymine
CAS No.	141039-00-1
Molecular Formula	C11H17N3O5
Molecular Weight	271.27 g/mol
Synonyms	3'-Methylamino-2',3'-dideoxythymidine; 3'-Methylamino-ddT; 1-[(2R,5S)-5-(Methylamino)-2,5-dihydro-2-furanyl]-5-methyl-2,4(1H,3H)-pyrimidinedione; 3'-N-Methyl-2',3'-dideoxythymidine; 3'-N-Methyl-ddT; 3'-Methylamino-2',3'-dideoxyribosylthymine; 3'-MA-ddT
EINECS	Contact for details

Quality Control

Our 3'-Methylamino-2',3'-Dideoxyribosylthymine is produced under strict quality management systems to ensure batch-to-batch consistency and high purity suitable for research applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles. We adhere to relevant industry standards for research-grade chemicals, and specifications can be tailored to meet specific project requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (typically 15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under dry conditions to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.