Description

2-Iodo-5'-Ethylcarboxamidoadenosine is a chemically modified adenosine derivative, specifically engineered as a potent and selective agonist for adenosine receptors. This compound is critical for advanced biochemical research and pharmaceutical development, offering a valuable tool for studying purinergic signaling pathways. It is primarily utilized by research institutions, pharmaceutical R&D departments, and biotechnology companies focused on neuroscience, cardiology, and inflammation.

Application

• Biochemical Research: A key tool for investigating adenosine A1, A2A, A2B, and A3 receptor subtypes and their associated signal transduction mechanisms.
• Pharmaceutical R&D: Serves as a reference standard and a critical intermediate in the discovery and development of novel therapeutics targeting adenosine receptors.
• Neuroscience Studies: Used in models to study neuroprotection, modulation of neurotransmitter release, and conditions like ischemia and sleep regulation.
• Cardiovascular Research: Applied in research exploring heart rate regulation, coronary blood flow, and ischemic preconditioning.
• Immunology and Inflammation: Investigated for its role in modulating immune cell function and inflammatory responses.
• In Vitro Assay Development: Employed as a high-affinity ligand in binding assays (e.g., radioligand binding) and functional cellular assays to screen for receptor modulators.

Basic Information

Product Name	2-Iodo-5'-Ethylcarboxamidoadenosine
CAS No.	141018-29-3
Molecular Formula	C13H16IN7O4
Molecular Weight	461.21 g/mol
Synonyms	2-Iodo-NECA; 2-Iodo-5'-N-ethylcarboxamidoadenosine; 5'-(N-Ethylcarboxamido)-2-iodoadenosine; 2-I-5'-N-ethylcarboxamidoadenosine; NECA, 2-Iodo-; Adenosine, 2-iodo-5'-(N-ethylcarboxamido)-; 2-I-Ado-5'-NECA; I-ECA
EINECS	Contact for details

Quality Control

Every batch of 2-Iodo-5'-Ethylcarboxamidoadenosine is manufactured under strict quality management systems and undergoes comprehensive analytical testing to ensure identity, purity, and consistency. We provide full traceability and Certificates of Analysis (COA) are available for all shipments, detailing key parameters such as assay, purity by HPLC, and residual solvent content. Our quality commitment aligns with the standards expected for research and pharmaceutical reference materials.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability. For long-term storage, consider desiccants and an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (IR)	Conforms
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.