Description

5'-Carboxy-2-Iodo-2',3'-o-Isopropylidene-D-Adenosine is a high-purity, protected nucleoside derivative designed for advanced pharmaceutical synthesis and biochemical research. This compound serves as a critical synthetic intermediate, enabling the precise construction of modified oligonucleotides and nucleotide analogs. It is essential for researchers and manufacturers in the fields of antiviral drug development, nucleoside chemistry, and probe synthesis who require reliable access to structurally complex building blocks.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of novel nucleoside-based therapeutics, including potential antiviral and anticancer agents.
• Oligonucleotide Synthesis: Used to introduce modified adenosine residues with specific functional handles (carboxyl and iodo groups) into DNA or RNA strands for research and diagnostic applications.
• Bioconjugation & Probe Development: The reactive iodo and carboxyl groups facilitate site-specific labeling and conjugation with fluorophores, biotin, or other molecules for creating biochemical probes.
• Medicinal Chemistry Research: Employed in structure-activity relationship (SAR) studies to explore new chemical space around the adenosine scaffold.
• Academic & Institutional Research: A valuable reagent for studies in enzymology, molecular biology, and chemical biology requiring tailored nucleotide structures.

Basic Information

Product Name	5'-Carboxy-2-Iodo-2',3'-o-Isopropylidene-D-Adenosine
CAS No.	141018-26-0
Molecular Formula	C14H16IN5O5
Molecular Weight	461.21 g/mol
Synonyms	2-Iodo-2',3'-O-isopropylideneadenosine-5'-carboxylic acid; 2-Iodo-N6-(2,2-dimethyl-4,6-dioxo-1,3-dioxan-5-yl)-9-(2,3-O-isopropylidene-β-D-ribofuranosyl)purine-5'-carboxamide; 5'-Carboxy-2-iodo-2',3'-O-isopropylideneadenosine; 2-Iodo-2',3'-O-isopropylideneadenosine-5'-carboxylic Acid; Protected 2-Iodoadenosine-5'-carboxylic Acid; D-Adenosine, 5'-carboxy-2-iodo-2',3'-O-(1-methylethylidene)-
EINECS	Contact for details

Quality Control

Every batch of 5'-Carboxy-2-Iodo-2',3'-o-Isopropylidene-D-Adenosine is manufactured and tested under a strict quality management system. We provide comprehensive analytical data to ensure the identity, purity, and consistency required for sensitive research and cGMP starting material applications. Certificates of Analysis (COA) detailing specifications such as HPLC purity, NMR confirmation, and residual solvent levels are available for all commercial quantities.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.