Description

2-Iodo-2',3'-o-Isopropylidene-D-Adenosine is a high-purity, protected nucleoside derivative, a critical intermediate in the synthesis of modified oligonucleotides and nucleotide analogs. This compound is essential for pharmaceutical research and development, particularly in the creation of antiviral and anticancer agents, due to its reactive iodine moiety which enables site-specific cross-coupling reactions. It is primarily utilized by research institutions, pharmaceutical R&D departments, and fine chemical manufacturers specializing in nucleotide chemistry and prodrug development.

Application

• Pharmaceutical Intermediate: A key building block for the synthesis of novel nucleoside-based antiviral and anticancer prodrugs.
• Oligonucleotide Synthesis: Used in the preparation of modified oligonucleotides for antisense therapy, siRNA, and diagnostic probes.
• Medicinal Chemistry Research: Serves as a versatile precursor for structure-activity relationship (SAR) studies and library synthesis in drug discovery.
• Bioconjugation: The iodine atom facilitates efficient cross-coupling reactions (e.g., Sonogashira, Suzuki) for labeling or attaching other functional molecules.
• Enzyme Substrate Studies: Employed in biochemical research to study the activity and inhibition of kinases and other nucleoside-processing enzymes.

Basic Information

Product Name	2-Iodo-2',3'-o-Isopropylidene-D-Adenosine
CAS No.	141018-25-9
Molecular Formula	C13H16IN5O4
Molecular Weight	433.20 g/mol
Synonyms	2-Iodoadenosine 2',3'-Isopropylidene acetal; 2-Iodo-2',3'-O-isopropylideneadenosine; 2-Iodo-N6-(2,2-dimethyl-1,3-dioxolan-4-yl)adenine; 9-[(2R,3R,4R,5R)-3,4-Isopropylidenedioxy-5-(hydroxymethyl)oxolan-2-yl]-2-iodo-9H-purin-6-amine; 2-Iodo-2',3'-O-(1-methylethylidene)adenosine; Protected 2-Iodoadenosine; D-Adenosine, 2-iodo-2',3'-O-(1-methylethylidene)-
EINECS	Contact for details

Quality Control

Every batch of 2-Iodo-2',3'-o-Isopropylidene-D-Adenosine is manufactured under controlled conditions and undergoes rigorous analytical testing to ensure identity, purity, and consistency. Our quality assurance protocols are designed to meet the stringent requirements of research and pharmaceutical development. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles by HPLC, NMR, and mass spectrometry is provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C (refrigerated) or as indicated on the label or COA. This product is hygroscopic (moisture-sensitive) and light-sensitive; ensure containers are sealed tightly after each use to minimize exposure to moisture and light.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines
Specific Rotation	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.