Description

1,4-Anhydro-2-Deoxy-2-(Thymin-1-Yl)-D-Arabinitol is a specialized nucleoside analogue, a key building block in medicinal chemistry and oligonucleotide synthesis. Its primary value lies in its role as a modified thymidine precursor, enabling the development of novel therapeutic agents and research tools. This high-purity intermediate is essential for pharmaceutical R&D, diagnostic development, and advanced life science applications requiring precise molecular modifications.

Application

• Pharmaceutical Intermediate: Critical building block for the synthesis of novel antiviral and anticancer nucleoside analogues.
• Oligonucleotide Synthesis: Used in the production of modified DNA/RNA strands for antisense therapy, siRNA, and aptamer development.
• Medicinal Chemistry Research: Serves as a key scaffold for structure-activity relationship (SAR) studies and prodrug design.
• Diagnostic Probe Development: Incorporated into labeled probes for molecular diagnostics and bioimaging.
• Bioconjugation: Enables the site-specific attachment of therapeutic payloads or reporter molecules.
• Academic & Contract Research: Fundamental reagent for studying nucleic acid chemistry, enzyme mechanisms, and metabolic pathways.

Basic Information

Product Name	1,4-Anhydro-2-Deoxy-2-(Thymin-1-Yl)-D-Arabinitol
CAS No.	140623-93-4
Molecular Formula	C10H14N2O5
Molecular Weight	242.23 g/mol
Synonyms	1,4-Anhydro-2-deoxy-2-(thymin-1-yl)-D-arabinitol; 2'-Deoxy-2'-(thymin-1-yl)-D-arabinitol 1,4-anhydride; Thymine arabinoside anhydride; 1-(2,5-Anhydro-β-D-arabinofuranosyl)thymine; 2,5-Anhydro-1-(2-deoxy-β-D-erythro-pentofuranosyl)thymine; Anhydrothymidine arabinoside; Modified Nucleoside AN-2-T-dA
EINECS	Contact for details

Quality Control

Our 1,4-Anhydro-2-Deoxy-2-(Thymin-1-Yl)-D-Arabinitol is manufactured under strict quality management systems. Each batch is subjected to rigorous analytical testing, including HPLC for purity and identity confirmation by IR and NMR, to ensure it meets the high standards required for pharmaceutical and research applications. A comprehensive Certificate of Analysis (COA) detailing purity, impurities, and physical characteristics is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept sealed in a dry environment to prevent product degradation. For long-term storage, consider desiccants or inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.