Description

5-Carboranyl-2'-Deoxyuridine is a boron-containing nucleoside analog, a key intermediate in the development of Boron Neutron Capture Therapy (BNCT) agents. This compound matters for its unique ability to deliver a high concentration of boron-10 isotopes to target cells, enabling precise, tumor-selective radiation therapy. It is primarily needed by pharmaceutical R&D teams, radiopharmaceutical manufacturers, and academic research institutions focused on oncology and novel radiotherapy modalities.

Application

• Boron Neutron Capture Therapy (BNCT): Serves as a critical precursor for synthesizing advanced boron delivery agents for experimental cancer treatment.
• Radiopharmaceutical Development: Used in research for creating targeted therapeutic and diagnostic agents.
• Oncology Research: A valuable tool for studying cell uptake mechanisms and the efficacy of boronated compounds in vitro and in vivo.
• Medicinal Chemistry: Employed as a building block for synthesizing novel nucleoside analogs with potential antiviral or anticancer activity.
• Biochemical Research: Used to investigate the incorporation of modified nucleosides into DNA and their biological effects.
• Isotope Labeling Studies: Facilitates research involving boron-10 tracing and localization within biological systems.

Basic Information

Product Name	5-Carboranyl-2'-Deoxyuridine
CAS No.	140424-79-9
Molecular Formula	C11H20B10N2O5
Molecular Weight	~386.07 g/mol (Contact for details)
Synonyms	5-(1,2-Dicarba-closo-dodecaboran(12)-1-yl)-2'-deoxyuridine; 5-(o-Carboranyl)-2'-deoxyuridine; 5-Carboranyldeoxyuridine; 5-(Dodecahydro-1,2-dicarba-closo-dodecaboran-1-yl)-2'-deoxyuridine; Boronated deoxyuridine; BNCT precursor; 5-(1,2-Dicarbadodecaboran(12)-1-yl)-2'-deoxyuridine
EINECS	Contact for details

Quality Control

Our 5-Carboranyl-2'-Deoxyuridine is produced under strict quality management protocols to ensure high purity and batch-to-batch consistency, essential for sensitive research and development applications. Each batch is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We support compliance with cGMP standards for advanced pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and light-sensitive; therefore, containers must be kept tightly sealed in a desiccated environment and handled under appropriate conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 2.0%
Heavy Metals	≤ 20 ppm
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.