Description

Nbd-Cocl CAS NO 140164-85-8 is a specialized chemical reagent widely recognized for its utility as a key intermediate in advanced organic synthesis and bioconjugation chemistry. Its primary value lies in its reactive functional groups, which enable precise labeling and modification of biomolecules and other substrates. This compound is essential for researchers and manufacturers in the pharmaceutical, biotechnology, and life science sectors, where it is used to develop novel probes, diagnostic agents, and targeted therapeutic conjugates.

Application

• Bioconjugation Reagent: Used for the covalent attachment of fluorescent or affinity tags to proteins, antibodies, and peptides for imaging and detection studies.
• Pharmaceutical Intermediate: Serves as a critical building block in the synthesis of active pharmaceutical ingredients (APIs) and targeted drug delivery systems.
• Fluorescent Probe Synthesis: Acts as a precursor for creating sensitive and selective fluorescent probes used in cellular imaging and bioassays.
• Chemical Biology Research: Employed in the development of activity-based probes (ABPs) to study enzyme function and mechanism.
• Diagnostic Agent Development: Utilized in the manufacturing of contrast agents and molecular diagnostic tools.
• Material Science: Applied in the surface functionalization of polymers and nanoparticles for specialized material properties.

Basic Information

Product Name	Nbd-Cocl
CAS No.	140164-85-8
Molecular Formula	C13H8ClN3O4
Molecular Weight	305.67 g/mol
Synonyms	7-Chloro-4-nitrobenzofurazan-2-carbonyl Chloride; 7-Chloro-4-nitrobenz-2-oxa-1,3-diazole-2-carbonyl Chloride; NBD-COCl; 4-Nitro-7-chlorobenzofurazan-2-carbonyl Chloride; 7-Chloro-4-nitro-2,1,3-benzoxadiazole-2-carbonyl Chloride; NBD-Carbonyl Chloride; 7-Chloro-4-nitrobenzo-2-oxa-1,3-diazole-2-carbonyl Chloride
EINECS	Contact for details

Quality Control

Our Nbd-Cocl is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity. Each lot undergoes comprehensive analytical testing, including HPLC for purity assessment and spectroscopic methods for structural confirmation. A Certificate of Analysis (COA) detailing all specifications is provided with every shipment to guarantee compliance with your research or production requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	Yellow to orange crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 1.0%
Solubility	Soluble in common organic solvents (DMSO, DMF, THF)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.