Description

Cyclazosin CAS NO 139953-73-4 is a selective α-1B adrenergic receptor antagonist of significant interest in pharmacological research. This compound matters as a critical tool for studying receptor subtype specificity and for the development of targeted cardiovascular and urological therapeutics. It is primarily needed by pharmaceutical R&D laboratories, academic research institutions, and contract research organizations (CROs) focused on neuropharmacology and drug discovery.

Application

• Pharmacological Research: Used as a selective antagonist to study the function and distribution of α-1B adrenergic receptor subtypes in vitro and in vivo.
• Drug Discovery Programs: Serves as a reference compound and a starting point for the design of new molecules targeting hypertension, benign prostatic hyperplasia (BPH), and other conditions mediated by adrenergic pathways.
• Biochemical Assay Development: Employed in high-throughput screening (HTS) and receptor binding assays to identify and characterize new drug candidates.
• Academic Neuroscience Studies: Utilized in university and institutional labs to investigate the role of specific adrenergic receptors in the central and peripheral nervous systems.
• Safety Pharmacology: Applied in preclinical studies to assess the cardiovascular effects and receptor selectivity profiles of new chemical entities.

Basic Information

Item	Details
Product Name	Cyclazosin
CAS No.	139953-73-4
Molecular Formula	C20H21N5O2
Molecular Weight	363.42 g/mol
Synonyms	Cyclazosin; L-765,314; 5-[2-[4-(2-Methoxyphenyl)-1-piperazinyl]ethyl]-2,4(1H,3H)-quinazolinedione; L765314; L 765314; (2,4-Dioxo-1,2,3,4-tetrahydroquinazolin-5-yl)ethyl-4-(2-methoxyphenyl)piperazine; Quinazoline-2,4(1H,3H)-dione, 5-[2-[4-(2-methoxyphenyl)-1-piperazinyl]ethyl]-
EINECS	Contact for details

Quality Control

Our Cyclazosin is produced under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via NMR and mass spectrometry, to ensure it meets the high standards required for research applications. A comprehensive Certificate of Analysis (COA) detailing purity, impurities, and analytical methods is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider desiccants or inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.