Description

4'-Methylthymidine is a modified nucleoside analog, a key building block in organic synthesis and pharmaceutical research. Its structural modification at the 4' position of the ribose sugar makes it a valuable intermediate for developing novel antiviral and anticancer agents, particularly in the synthesis of nucleoside reverse transcriptase inhibitors. This high-purity compound is essential for researchers and manufacturers in the pharmaceutical, biotechnology, and fine chemical sectors who require reliable, high-quality intermediates for advanced therapeutic development.

Application

• Pharmaceutical Intermediate: Critical building block for the synthesis of novel nucleoside-based antiviral and anticancer drugs.
• Biochemical Research: Used in studies investigating DNA/RNA metabolism, enzyme mechanisms, and the structure-activity relationships of nucleoside analogs.
• Antiviral Drug Development: Serves as a precursor in the research and production of potential therapeutics targeting viruses such as HIV, Hepatitis B, and Herpes.
• Proteomics & Genomics: Employed in the synthesis of labeled nucleosides for use as probes or tracers in molecular biology assays.
• Fine Chemical Synthesis: A versatile intermediate for creating specialized nucleoside derivatives with tailored properties for various applications.
• Academic & Contract Research: Supplied to universities and CROs (Contract Research Organizations) for discovery chemistry and medicinal chemistry programs.

Basic Information

Product Name	4'-Methylthymidine
CAS No.	139925-84-1
Molecular Formula	C11H16N2O5
Molecular Weight	256.26 g/mol
Synonyms	4'-C-Methylthymidine; 1-[(2R,4R,5R)-4-Hydroxy-5-(hydroxymethyl)-4-methyloxolan-2-yl]-5-methylpyrimidine-2,4-dione; 4'-Methyl-2'-deoxythymidine; Thymidine, 4'-methyl-; 2'-Deoxy-4'-methylthymidine
EINECS	Contact for details

Quality Control

Our 4'-Methylthymidine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity assessment and NMR/IR for structural confirmation, to ensure it meets the high standards required for pharmaceutical research and development. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with every shipment and is available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.