Description

2-Cyclobutene-1-Carboxylic Acid, 4-(Chlorocarbonyl)-, Methyl Ester, cis- (9Ci) is a high-purity, specialized organic building block featuring a reactive cyclobutene core and an acid chloride functionality. This compound is valued for its role as a key synthetic intermediate in advanced organic synthesis, enabling the construction of complex molecular architectures. It is primarily sought by research and development teams in the pharmaceutical and agrochemical sectors for the development of novel active ingredients and fine chemicals.

Application

• Pharmaceutical Intermediate: Serves as a critical precursor in the synthesis of novel drug candidates, particularly those requiring strained ring systems for biological activity.
• Agrochemical Synthesis: Used in the research and development of new herbicides, fungicides, and insecticides with unique modes of action.
• Material Science Research: Acts as a monomer or cross-linking agent in the development of advanced polymers with specific thermal or mechanical properties.
• Organic Synthesis Building Block: Provides a versatile platform for [4+2] cycloaddition (Diels-Alder) reactions and other transformations to create complex, polycyclic structures.
• Ligand and Catalyst Development: Utilized in the preparation of specialized ligands for asymmetric catalysis and metal-organic frameworks (MOFs).
• Chemical Biology Probes: Employed in the synthesis of molecular probes for studying enzyme mechanisms and protein interactions.

Basic Information

Item	Detail
Product Name	2-Cyclobutene-1-Carboxylic Acid, 4-(Chlorocarbonyl)-, Methyl Ester, cis- (9Ci)
CAS No.	139591-41-6
Molecular Formula	C7H7ClO3
Molecular Weight	174.58 g/mol
Synonyms	Methyl 4-(chlorocarbonyl)-2-cyclobutene-1-carboxylate, cis-; cis-Methyl 4-(chloroformyl)-2-cyclobutene-1-carboxylate; 2-Cyclobutene-1-carboxylic acid, 4-(chlorocarbonyl)-, methyl ester, (1s,4r)-rel-; 4-(Chlorocarbonyl)-2-cyclobutene-1-carboxylic acid methyl ester; Methyl cis-4-(chlorocarbonyl)cyclobut-2-ene-1-carboxylate; Cyclobut-2-ene-1,4-dicarboxylic acid 4-chloride 1-methyl ester; (1s,4r)-4-(Chlorocarbonyl)cyclobut-2-ene-1-carboxylic acid methyl ester
EINECS	Contact for details

Quality Control

Our production of 2-Cyclobutene-1-Carboxylate derivatives adheres to stringent internal quality protocols to ensure batch-to-batch consistency and high purity. Each lot is analyzed using advanced chromatographic and spectroscopic techniques. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with every shipment to support your quality assurance and regulatory documentation.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic and moisture-sensitive nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent hydrolysis and degradation. Keep away from strong bases and oxidizing agents.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Related Substances (HPLC)	Total impurities ≤ 3.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.