Description

3'-Fluoro-2',3'-Dideoxythymidine-5'-(α-Methylphosphonyl)-Beta,γ-Diphosphate is a chemically modified nucleoside analog, specifically a thymidine derivative with a fluorinated sugar moiety and a complex phosphonate-diphosphate chain. This compound is a critical building block and a key intermediate in the research and development of novel antiviral and anticancer therapeutics, particularly those targeting viral polymerases and cellular nucleotide metabolism. It is essential for pharmaceutical R&D laboratories, biotechnology companies, and academic institutions focused on nucleotide chemistry, prodrug development, and the synthesis of next-generation antiviral agents.

Application

• Antiviral Drug Development: Serves as a crucial precursor in the synthesis of nucleotide reverse transcriptase inhibitors (NRTIs) and other antiviral prodrugs.
• Oncology Research: Used as a modified nucleoside intermediate in the development of chemotherapeutic agents that target DNA synthesis and repair mechanisms in cancer cells.
• Biochemical Research: Acts as a substrate or inhibitor in enzymatic studies to investigate the mechanisms of viral polymerases (e.g., HIV reverse transcriptase) and cellular DNA polymerases.
• Prodrug Synthesis: The unique phosphonate-diphosphate structure makes it a valuable scaffold for designing membrane-permeable prodrugs with enhanced bioavailability.
• Medicinal Chemistry: A key intermediate for structure-activity relationship (SAR) studies to optimize the potency and selectivity of nucleotide-based pharmaceuticals.
• Diagnostic Probe Development: Can be utilized in the creation of labeled probes for studying nucleotide incorporation and metabolic pathways.

Basic Information

Product Name	3'-Fluoro-2',3'-Dideoxythymidine-5'-(α-Methylphosphonyl)-Beta,γ-Diphosphate
CAS No.	139459-42-0
Molecular Formula	C11H17FN2O12P3
Molecular Weight	466.17 g/mol
Synonyms	3'-F-ddT-5'-(α-Methylphosphonyl)-β,γ-diphosphate; 3'-Fluoro-2',3'-dideoxythymidine 5'-(α-methylphosphonyl)-β,γ-diphosphate; 3'-F-ddTMPP; 5'-(α-Methylphosphonyl)-β,γ-diphosphate of 3'-Fluoro-2',3'-dideoxythymidine; FLT Diphosphate Analog; Nucleoside Phosphonate Diphosphate Intermediate; Antiviral Nucleotide Intermediate; CAS 139459-42-0
EINECS	Contact for details

Quality Control

Our production of 3'-Fluoro-2',3'-Dideoxythymidine-5'-(α-Methylphosphonyl)-Beta,γ-Diphosphate adheres to stringent quality protocols suitable for research and pharmaceutical intermediate applications. Each batch undergoes comprehensive analytical characterization including HPLC for purity assessment, NMR for structural confirmation, and mass spectrometry. We provide full traceability and Certificates of Analysis (COA) detailing identity, purity, and impurity profiles to support your regulatory and research documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This compound is hygroscopic (moisture-sensitive) and light-sensitive. For long-term storage, consider under an inert atmosphere to ensure stability.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Retention time corresponds to reference standard
Identification (NMR)	Spectrum consistent with structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 2.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.