Description

4'-C-Azidouridine is a chemically modified nucleoside analog, specifically a uridine derivative with an azido group at the 4'-carbon position of the ribose sugar. This unique structure makes it a valuable intermediate and building block in synthetic organic chemistry and medicinal research. It is primarily utilized by researchers and manufacturers in the pharmaceutical and biotechnology sectors for the development of novel therapeutic agents and diagnostic probes. Its application is critical in areas such as nucleoside chemistry, prodrug design, and the synthesis of labeled compounds for biological studies.

Application

• Pharmaceutical Intermediate: Serves as a key synthetic precursor for the development of novel antiviral and anticancer nucleoside analogs.
• Medicinal Chemistry Research: Used as a building block in structure-activity relationship (SAR) studies to explore new therapeutic candidates.
• Bioconjugation and Probe Synthesis: The reactive azido group enables click chemistry (e.g., CuAAC) for labeling biomolecules, creating fluorescent probes, or developing targeted drug delivery systems.
• Biochemical Tool Development: Employed in the synthesis of modified nucleotides for studying enzyme mechanisms, such as those involving polymerases or nucleoside kinases.
• Academic and R&D Laboratories: A critical reagent for fundamental research in organic synthesis, chemical biology, and nucleic acid chemistry.

Basic Information

Product Name	4'-C-Azidouridine
CAS No.	139442-01-6
Molecular Formula	C9H11N5O6
Molecular Weight	285.22 g/mol
Synonyms	4'-Azidouridine; 1-((2R,3R,4S,5R)-3-Azido-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)pyrimidine-2,4(1H,3H)-dione; 4'-Azido-2'-deoxyuridine (common misnomer, verify structure); Uridine, 4'-azido-; 4'-C-N3-Uridine; Azidouridine; 4'-Azido derivative of uridine
EINECS	Contact for details

Quality Control

Every batch of 4'-C-Azidouridine is manufactured and tested under strict quality management protocols to ensure identity, purity, and consistency. Our products undergo rigorous quality testing to ensure compliance with industry standards. Certificates of Analysis (COA) are available upon request, detailing comprehensive analytical results from techniques including HPLC, NMR, and mass spectrometry.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This compound is hygroscopic (moisture-sensitive) and light-sensitive; therefore, containers must be kept tightly sealed in a desiccated environment and handled under appropriate conditions to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 2.0%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.