Description

n-Benzoyl-2'-o-[(Methylthio)Methyl]-3',5'-o-[1,1,3,3-Tetrakis(1-Methylethyl)-1,3-Disiloxanediyl]Cytidine is a sophisticated, protected nucleoside derivative designed for advanced oligonucleotide synthesis. This compound matters because it provides critical protection for the cytidine base and ribose sugar during complex solid-phase synthesis, ensuring high coupling efficiency and preventing unwanted side reactions. It is an essential building block for researchers and manufacturers in the pharmaceutical and biotechnology sectors developing novel antisense oligonucleotides, siRNA, and other therapeutic nucleic acids.

Application

• Solid-Phase Oligonucleotide Synthesis: A key phosphoramidite precursor for the automated synthesis of DNA and RNA strands.
• Antisense Oligonucleotide (ASO) Development: Used in the research and production of ASO therapeutics targeting genetic diseases.
• siRNA and miRNA Synthesis: Critical for constructing short interfering RNA (siRNA) and microRNA (miRNA) molecules for gene silencing applications.
• Pharmaceutical Intermediate: Serves as a high-purity intermediate in the synthesis of nucleoside-based antiviral and anticancer drugs.
• Diagnostic Probe Manufacture: Employed in creating labeled nucleic acid probes for diagnostic assays and genomic research.
• Academic and Industrial R&D: A vital reagent for chemical biology research exploring nucleic acid structure, function, and modification.

Basic Information

Item	Details
Product Name	n-Benzoyl-2'-o-[(Methylthio)Methyl]-3',5'-o-[1,1,3,3-Tetrakis(1-Methylethyl)-1,3-Disiloxanediyl]Cytidine
CAS No.	139434-68-7
Molecular Formula	C33H51N3O6SSi2
Molecular Weight	673.99 g/mol
Synonyms	5'-O-(1,1,3,3-Tetraisopropyldisiloxane-1,3-diyl)-N-benzoyl-2'-O-[(methylthio)methyl]cytidine; 2'-O-MTM-3',5'-O-TIPDS-N-benzoylcytidine; N4-Benzoyl-2'-O-(methylthiomethyl)-3',5'-O-(1,1,3,3-tetraisopropyl-1,3-disiloxanediyl)cytidine; 2'-O-MTM-5'-O-TIPDS-N-Bz-Cytidine; Protected Cytidine Derivative; Cytidine, N-benzoyl-2'-O-[(methylthio)methyl]-, 3',5'-bis(1,1-dimethylethyl)disiloxanediyl deriv.; MTM-TIPDS-N-Bz-Cytidine
EINECS	Contact for details

Quality Control

Our n-Benzoyl-2'-o-[(Methylthio)Methyl]-3',5'-o-[1,1,3,3-Tetrakis(1-Methylethyl)-1,3-Disiloxanediyl]Cytidine is manufactured under strict quality systems to ensure batch-to-batch consistency for sensitive synthetic applications. All materials undergo rigorous analytical testing, including HPLC for purity and identity confirmation by NMR and MS. Certificates of Analysis (COA) detailing all specifications are provided with each shipment to support your quality and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This product is hygroscopic (moisture-sensitive) and should be handled under a dry inert atmosphere (e.g., nitrogen or argon) when opening to prevent degradation. For long-term storage, desiccate at -20°C.

Specification

Item	Specification
Appearance	White to off-white powder or solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.