Description

N6-Benzoyl-2'-Deoxy-5-o-Dmt-Adenosine 3'-Phosphonate Triethylammonium Salt is a key, high-purity phosphoramidite monomer used in the automated synthesis of oligonucleotides. This compound is critical for ensuring high coupling efficiency and sequence fidelity in the production of DNA and RNA strands for research and therapeutic applications. It is an essential raw material for biotechnology, pharmaceutical R&D, and diagnostic kit manufacturers requiring precise and reliable oligonucleotide synthesis.

Application

• Oligonucleotide Synthesis: As a protected adenosine phosphoramidite monomer in solid-phase DNA/RNA synthesizers.
• Antisense Drug Development: For the research-scale and GMP production of antisense oligonucleotides (ASOs) and siRNA.
• PCR Primers & Probes: Manufacture of high-purity primers and fluorescently labeled probes for molecular diagnostics and qPCR.
• Gene Synthesis & Cloning: Building blocks for the chemical synthesis of long DNA fragments and genes.
• Next-Generation Sequencing (NGS): Production of custom adapters, barcodes, and other oligonucleotide components for sequencing platforms.
• Aptamer Development: Synthesis of modified DNA libraries for SELEX processes to discover therapeutic aptamers.
• Academic & Industrial Research: Fundamental biochemical research involving nucleic acid chemistry and modification.

Basic Information

Product Name	N6-Benzoyl-2'-Deoxy-5-o-Dmt-Adenosine 3'-Phosphonate Triethylammonium Salt
CAS No.	139290-39-4
Molecular Formula	C46H55N6O8P • C6H15N
Molecular Weight	~917.0 g/mol
Synonyms	5'-O-DMT-N6-benzoyl-2'-deoxyadenosine-3'-[(2-cyanoethyl)-(N,N-diisopropyl)]-phosphoramidite; dA(Bz) Phosphoramidite; 2'-Deoxy-5'-O-(4,4'-dimethoxytrityl)-N6-benzoyladenosine-3'-[(2-cyanoethyl)-N,N-diisopropyl]phosphoramidite; N6-Benzoyl-2'-deoxyadenosine-3'-phosphoramidite, DMT protected; dABz CE Phosphoramidite; Adenine, N-benzoyl-2'-deoxy-5'-O-[bis(4-methoxyphenyl)phenylmethyl]-, 3'-[2-cyanoethyl bis(1-methylethyl)phosphoramidite]; 5'-O-(4,4'-Dimethoxytrityl)-N6-benzoyl-2'-deoxyadenosine-3'-(2-cyanoethyl N,N-diisopropylphosphoramidite)
EINECS	Contact for details

Quality Control

Our products undergo rigorous quality testing to ensure compliance with industry standards for oligonucleotide synthesis. Each batch is characterized by HPLC, 31P NMR, and 1H NMR to confirm identity, purity, and stability. Certificates of Analysis (COA) detailing all specifications are available upon request, supporting applications in regulated environments.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere (argon or nitrogen) in a desiccated environment. This compound is hygroscopic (moisture-sensitive) and light-sensitive. Allow the sealed vial to equilibrate to room temperature before opening to prevent moisture condensation.

Specification

Item	Specification
Appearance	White to off-white solid or foam
Identification (HPLC)	Conforms to reference standard
Identification (31P NMR)	Conforms to reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Solubility	Clear, colorless solution in anhydrous acetonitrile

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.