Description

3'-Amino-3'-Deoxy-5'-o-Dmt-Thymidine is a crucial, chemically modified nucleoside derivative used as a key building block in oligonucleotide synthesis. Its primary value lies in enabling the precise construction of DNA and RNA analogs for advanced research and therapeutic development. This high-purity intermediate is essential for pharmaceutical R&D, biotechnology companies, and academic laboratories focused on antisense oligonucleotides, siRNA, and other nucleic acid-based technologies.

Application

• Oligonucleotide Synthesis: A vital phosphoramidite precursor for the solid-phase synthesis of modified DNA and RNA strands.
• Antisense Drug Development: Used in the research and production of antisense oligonucleotides (ASOs) designed to target specific RNA sequences.
• siRNA and miRNA Research: Incorporated into small interfering RNA (siRNA) or microRNA (miRNA) constructs to enhance stability and specificity.
• Diagnostic Probe Manufacture: Serves as a modified base in the creation of labeled probes for genetic testing and molecular diagnostics.
• Pharmaceutical Intermediates: Acts as a critical raw material in the synthesis of novel nucleoside-based active pharmaceutical ingredients (APIs).
• Bioconjugation and Labeling: The amino group provides a handle for further chemical modification, such as attachment of fluorophores or other reporter molecules.

Basic Information

Item	Details
Product Name	3'-Amino-3'-Deoxy-5'-o-Dmt-Thymidine
CAS No.	139063-29-9
Molecular Formula	C31H33N3O7
Molecular Weight	559.61 g/mol
Synonyms	5'-O-(4,4'-Dimethoxytrityl)-3'-amino-3'-deoxythymidine; 3'-Amino-5'-O-DMT-thymidine; 3'-NH2-5'-O-DMT-dT; 3'-Amino-3'-deoxy-5'-O-(4,4'-dimethoxytrityl)thymidine; DMT-3'-Amino-dT; 3'-Amino-2',3'-dideoxy-5'-O-DMT-thymidine; 3'-Amino-2',3'-dideoxythymidine 5'-O-(4,4'-dimethoxytrityl) ether
EINECS	Contact for details

Quality Control

Our 3'-Amino-3'-Deoxy-5'-o-Dmt-Thymidine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and stringent controls for moisture and related substances. We provide comprehensive Certificates of Analysis (COA) with each shipment to ensure traceability and compliance with your research or cGMP-grade requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This compound is hygroscopic (moisture-sensitive); therefore, containers must be kept sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. For long-term storage, consider storing at -20°C.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Single Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.