Description

8-Thiocyano-Adenosine Triphosphate is a chemically modified nucleotide analog where a thiocyano group replaces a specific oxygen atom on the adenosine triphosphate (ATP) molecule. This modification is critical for its role as a versatile biochemical tool in enzymatic studies and molecular biology research. It is primarily utilized by researchers in pharmaceutical R&D, academic institutions, and diagnostic kit manufacturers who require high-purity, specialized nucleotides for probing enzyme mechanisms and developing sensitive assays.

Application

• Enzyme Kinetics & Mechanism Studies: Used as a substrate or inhibitor to investigate the active sites and catalytic pathways of ATP-dependent enzymes like kinases and ATPases.
• Bioconjugation & Labeling: The reactive thiocyano group enables site-specific labeling of proteins, antibodies, or other biomolecules for creating detection probes.
• Diagnostic Assay Development: Serves as a key component in the development of luminescent or colorimetric diagnostic tests that monitor ATP-consuming reactions.
• Structural Biology: Employed in X-ray crystallography or NMR studies to capture snapshots of enzyme-substrate complexes.
• High-Throughput Screening (HTS): Acts as a substrate in HTS campaigns to identify novel modulators of target enzymes for drug discovery.
• Metabolic Pathway Analysis: Used to trace and study specific ATP-utilizing pathways within cellular systems.

Basic Information

Product Name	8-Thiocyano-Adenosine Triphosphate
CAS No.	139041-17-1
Molecular Formula	C11H15N6O12P3S
Molecular Weight	548.27 g/mol
Synonyms	8-Thiocyanato-ATP; 8-SCN-ATP; Adenosine 5'-(tetrahydrogen triphosphate), 8-thiocyano-; 8-Thiocyano-ATP; ATP-8-SCN; 8-SCN-Adenosine triphosphate; NSC 339539; 8-Thiocyanatoadenosine 5'-triphosphate
EINECS	Contact for details

Quality Control

Every batch of 8-Thiocyano-Adenosine Triphosphate is manufactured and tested under stringent quality management systems. We provide comprehensive analytical data to ensure the product meets the high-purity standards required for sensitive research applications. A detailed Certificate of Analysis (COA), including HPLC purity, identity confirmation (NMR/IR), and impurity profile, is supplied with each shipment to guarantee traceability and consistency.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This product is hygroscopic (moisture-sensitive). For long-term storage, consider desiccation and storage under inert atmosphere. Allow the sealed vial to equilibrate to room temperature before opening to minimize moisture condensation.

Specification

Item	Specification
Appearance	White to off-white powder or solid
Identification (HPLC)	Conforms to reference standard
Identification (NMR/IR)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 3.0%
Biological Activity	Tested in standard enzymatic assay

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.