Description

Manumycin B is a potent and specific natural product inhibitor of farnesyltransferase, an enzyme critical in the Ras signaling pathway. This targeted mechanism makes it a valuable research tool for studying oncogenesis, cell proliferation, and signal transduction. It is primarily utilized by researchers in pharmaceutical R&D, biotechnology, and academic institutions focused on cancer biology and drug discovery. The compound is supplied under the CAS registry number 139023-58-8.

Application

• Biochemical Research: Used as a specific inhibitor to study the farnesyltransferase enzyme and the post-translational modification of Ras and other proteins.
• Oncology Research: A critical tool for investigating Ras-driven cancer pathways, tumor cell proliferation, and potential therapeutic targets.
• Signal Transduction Studies: Employed to elucidate the role of protein prenylation in various cellular signaling cascades and disease mechanisms.
• Drug Discovery & Development: Serves as a lead compound or reference standard in high-throughput screening and the development of novel anti-cancer agents.
• Academic & Pharmaceutical R&D: Essential for basic research in molecular biology, cell biology, and pharmacology within university and industrial laboratories.

Basic Information

Product Name	Manumycin B
CAS No.	139023-58-8
Molecular Formula	C31H38N2O7
Molecular Weight	550.65 g/mol
Synonyms	Manumycin B; Antibiotic UCF1-B; UCF1-B; Farnesyltransferase inhibitor UCF1-B; (2E,4E,6E,8E)-9-[(2S,3R)-3-Hydroxy-2-[(1E,3E,5E)-6-[(2S,3S)-3-hydroxy-5-oxo-2,3-dihydro-1H-pyrrol-2-yl]-6-oxohexa-1,3,5-trien-1-yl]-5-oxo-2,3-dihydro-1H-pyrrol-1-yl]nona-2,4,6,8-tetraenoic acid
EINECS	Contact for details

Quality Control

Our Manumycin B is produced under strict quality management protocols to ensure batch-to-batch consistency and reliability for research applications. Each lot undergoes comprehensive analytical characterization, including HPLC for purity determination and spectroscopic methods for structural confirmation. A Certificate of Analysis (COA) detailing purity, identity, and other critical parameters is provided with every shipment to support your research documentation and compliance needs.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere. This product is hygroscopic (moisture-sensitive) and light-sensitive. Allow the vial to warm to room temperature in a desiccator before opening to prevent condensation and moisture uptake.

Specification

Item	Specification
Appearance	Yellow to brownish powder
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to structure
Purity (HPLC)	≥95%
Water Content (KF)	≤1.0%
Solubility	Soluble in DMSO, DMF; sparingly soluble in methanol

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.