Description

2'-Deoxyadenosine 5'-[Hydrogen [[Hydroxy(Phosphonooxy)Phosphinyl]Methyl]Phosphonate] is a chemically modified nucleoside analog of significant interest in advanced biochemical research and pharmaceutical development. This compound matters as a key building block and potential prodrug intermediate for the synthesis of novel antiviral and anticancer agents, particularly nucleotide analogs targeting viral polymerases. It is primarily needed by research institutions, pharmaceutical R&D departments, and fine chemical manufacturers focused on developing next-generation therapeutics.

Application

• Antiviral Drug Development: Serves as a critical precursor in the synthesis of nucleotide reverse transcriptase inhibitors (NRTIs) and other antiviral prodrugs.
• Oncology Research: Used as an intermediate for creating nucleoside-based chemotherapeutic agents that interfere with DNA synthesis in cancer cells.
• Biochemical Tool Compound: Employed in enzymatic studies to investigate the mechanism of action of polymerases and kinases.
• Prodrug Synthesis: Acts as a masked phosphate derivative (phosphoramidate or phosphonate prodrug) to enhance cellular uptake and bioavailability of active nucleotide metabolites.
• Medicinal Chemistry Research: Provides a versatile scaffold for structure-activity relationship (SAR) studies to optimize potency and selectivity of drug candidates.
• Labeled Compound Production: Can be used as a starting material for synthesizing isotopically labeled (e.g., 13C, 15N, 2H) analogs for metabolic tracing and pharmacokinetic studies.

Basic Information

Product Name	2'-Deoxyadenosine 5'-[Hydrogen [[Hydroxy(Phosphonooxy)Phosphinyl]Methyl]Phosphonate]
CAS No.	138998-91-1
Molecular Formula	C11H18N5O11P3
Molecular Weight	513.20 g/mol
Synonyms	2'-Deoxyadenosine-5'-[hydrogen (hydroxy(phosphonooxy)phosphoryl)methyl]phosphonate; dAMP-PCP; Deoxyadenosine 5'-(α,β-methylene)triphosphate analog; 2'-Deoxyadenosine 5'-(α,β-methylenetriphosphate); Adenosine 5'-[P1-(2-deoxy-β-D-erythro-pentofuranosyl), P3-(hydroxyphosphinyl)] triphosphate; dA-α,β-CH2-ATP; 5'-O-[(Hydroxy(phosphonooxy)phosphinyl)methyl]phosphono-2'-deoxyadenosine
EINECS	Contact for details

Quality Control

Our products undergo rigorous quality testing to ensure compliance with industry standards for research and pharmaceutical intermediates. We employ advanced analytical techniques including HPLC, NMR, and mass spectrometry to verify identity, purity, and consistency. Certificates of Analysis (COA) detailing batch-specific results for assay, purity, and related substances are available upon request. Production can be aligned with cGMP guidelines for advanced development phases.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a freezer. This compound is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions or a dry inert atmosphere to prevent decomposition. Allow the sealed container to equilibrate to room temperature before opening to minimize moisture ingress.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 3.0%
Related Substances (HPLC)	Total impurities ≤ 5.0%
Solubility	Soluble in water, DMSO; sparingly soluble in organic solvents

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.